{"id":"W4408403388","doi":"10.1101/2025.03.12.642847","title":"Influenza virus antagonizes self sensing by RIG-I to enhance viral replication","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Burroughs Wellcome Fund; National Science Foundation","keywords":"Virology; Replication (statistics); Viral replication; Virus; Influenza A virus; RIG-I; Avian influenza virus; Influenza A virus subtype H5N1; Biology; Immune system; Genetics; Innate immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002174051,0.0003490908,0.0002044026,0.0001678781,0.0001082512,0.0003646118,0.0001766183,0.0003022377,0.001715292],"category_scores_gemma":[0.0001442713,0.000111304,0.0002428285,0.00006810753,0.0002113708,0.0002309328,0.0003343809,0.0005799811,0.0008331597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002425576,"about_ca_system_score_gemma":0.0001767118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002423865,"about_ca_topic_score_gemma":0.0003607591,"domain_scores_codex":[0.9998115,0.00004137517,0.00001336237,0.00003266488,0.00004988367,0.00005124172],"domain_scores_gemma":[0.9999279,0.00001205662,0.00001769382,0.00001706067,0.000007665187,0.00001772362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004612338,0.000007329367,0.00008344102,0.00001738361,0.000002942824,0.00002030725,0.000003688102,0.00003777596,0.9989329,0.0002463713,0.00004339842,0.0005583588],"study_design_scores_gemma":[0.000007353603,0.0000621443,0.0009313168,0.000003438625,0.000004411216,0.0001039967,0.000007588644,0.001038127,0.995936,0.00008618244,0.00181706,0.000002328559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9718631,0.004562604,0.009949546,0.0003421432,0.0002335548,0.00005209225,0.0004888868,0.000313259,0.01219476],"genre_scores_gemma":[0.9903899,0.0006691928,0.004004403,0.000114271,0.00002712465,0.00002169096,0.0002862671,0.00004302654,0.004444072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001715292,"threshold_uncertainty_score":0.005738258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009232444300522889,"score_gpt":0.2607146509293041,"score_spread":0.2514822066287812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}