{"id":"W4408405629","doi":"10.1001/jamaoncol.2025.0029","title":"Veliparib Plus Temozolomide for <i>MGMT</i>-Methylated Glioblastoma","year":2025,"lang":"en","type":"article","venue":"JAMA Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Veliparib; Temozolomide; Medicine; Glioblastoma; Oncology; O-6-methylguanine-DNA methyltransferase; Cancer research; Internal medicine; Methylation; Genetics; Methyltransferase; Poly ADP ribose polymerase; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002236462,0.000181505,0.0005755101,0.0002362994,0.0001021195,0.00001944142,0.0001005741,0.0003490612,0.00009716398],"category_scores_gemma":[0.0003934918,0.0001485217,0.0001900359,0.0003387019,0.00007910025,0.00004310815,0.00006509407,0.0001764109,0.00008075366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005760894,"about_ca_system_score_gemma":0.0005009205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000624601,"about_ca_topic_score_gemma":0.0001672558,"domain_scores_codex":[0.9987677,0.00005974247,0.0003419997,0.000354079,0.0001017257,0.0003747183],"domain_scores_gemma":[0.9986309,0.0006529876,0.00009485895,0.0003092974,0.0001845047,0.0001274847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006473114,0.002787425,0.01354967,0.0003127631,0.001544555,0.0008132775,0.0003321503,0.00007743256,0.03755899,0.0147512,0.5111625,0.4106369],"study_design_scores_gemma":[0.02193905,0.00346914,0.01961704,0.0001218642,0.0006347666,0.00008442707,0.0001457231,0.001118469,0.05310005,0.001540095,0.8980563,0.0001731372],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9269185,0.00146432,0.0004974304,0.04135514,0.00110225,0.001765219,0.0000423792,0.0001877479,0.02666701],"genre_scores_gemma":[0.9879771,0.00007308486,0.002240283,0.007136482,0.0002174278,0.0006816153,0.00006246955,0.00002319562,0.001588289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4104638,"threshold_uncertainty_score":0.6056538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0164503816226078,"score_gpt":0.3369605497561127,"score_spread":0.3205101681335049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}