{"id":"W4408406092","doi":"10.3390/cancers17060972","title":"Evaluating Sorafenib (SORA-2) as Second-Line Treatment for Unresectable Hepatocellular Carcinoma: A European Retrospective Multicenter Study","year":2025,"lang":"en","type":"article","venue":"Cancers","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"","keywords":"Sorafenib; Medicine; Hepatocellular carcinoma; Internal medicine; Retrospective cohort study; Oncology; Cohort; Adverse effect; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003116066,0.0003425162,0.0005792881,0.0005631837,0.0003132958,0.0007764869,0.0003269569,0.0004526065,0.0009103249],"category_scores_gemma":[0.004343091,0.000238323,0.0006644467,0.0009027778,0.0003279365,0.000462134,0.0004956796,0.0003674303,0.0002146261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005202516,"about_ca_system_score_gemma":0.0006097223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008066061,"about_ca_topic_score_gemma":0.0007399889,"domain_scores_codex":[0.9980341,0.00104609,0.0002151301,0.000384101,0.0001852842,0.0001354402],"domain_scores_gemma":[0.994476,0.001069728,0.003146218,0.0003836008,0.0004221344,0.0005022371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001772716,0.0001894337,0.9939005,0.00005448473,0.000258064,0.0002015752,0.00007935075,0.00007667489,0.0004644211,0.00002125843,0.000116843,0.002864653],"study_design_scores_gemma":[0.0004398809,0.002775447,0.991941,0.00004955943,0.0004469459,0.001894536,0.0004425642,0.0004457312,0.0005382465,0.00002618539,0.0009847449,0.00001497295],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986028,0.000961728,0.0001102317,0.00003077167,0.000004368152,0.00002569829,0.0001136356,0.000002212365,0.0001484328],"genre_scores_gemma":[0.9993073,0.0002153914,0.0001004973,0.00005255132,0.00001546363,0.00002662303,0.0002487742,0.000002726725,0.0000305637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003116066,"threshold_uncertainty_score":0.01647955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1093379468694185,"score_gpt":0.3532501687693204,"score_spread":0.2439122218999019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}