{"id":"W4408412481","doi":"10.1136/jmg-2024-110465","title":"Canadian consensus for the assessment and testing of Lynch syndrome","year":2025,"lang":"en","type":"article","venue":"Journal of Medical Genetics","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Stollery Children's Hospital; University of Alberta Hospital; Princess Margaret Cancer Centre; Sunnybrook Health Science Centre; Sinai Health System; University of British Columbia; William Osler Health System; Alberta Hospital Edmonton; Izaak Walton Killam Health Centre; Saskatchewan Health; Saskatchewan Health Authority; Memorial University of Newfoundland; University of Toronto; Hospital for Sick Children; Western University; Brampton Civic Hospital; Manitoba Health; Health Sciences Centre; University Health Network; Dr. H. Bliss Murphy Cancer Centre; University of Manitoba; CancerCare Manitoba; Children's Hospital of Eastern Ontario; McGill University Health Centre; McGill University; Alberta Health Services; BC Cancer Agency","funders":"","keywords":"Lynch syndrome; Genetic testing; Carrier testing; Guideline; Medicine; Health care; Family medicine; Political science; Cancer; Genetics; Internal medicine; Pathology; Biology; DNA mismatch repair; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02981556,0.001122256,0.001315835,0.008277792,0.004779589,0.003363002,0.006946956,0.006982537,0.01408352],"category_scores_gemma":[0.08260134,0.000847941,0.003196112,0.005659755,0.003071385,0.001485553,0.003997355,0.006138945,0.004789495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.04560506,"about_ca_system_score_gemma":0.215636,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.7410582,"about_ca_topic_score_gemma":0.7584474,"domain_scores_codex":[0.961943,0.008844681,0.005538461,0.001391334,0.01962164,0.002660838],"domain_scores_gemma":[0.8542835,0.0100946,0.003439931,0.002163853,0.1229964,0.007021824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007525703,0.00003760611,0.003075734,0.003128257,0.0000843063,0.0007523431,0.001369769,0.0005356906,0.0005871107,0.01297697,0.800687,0.17669],"study_design_scores_gemma":[0.00008670719,0.00003000435,0.008230022,0.008388024,0.00009546054,0.001227034,0.0008401498,0.000336117,0.0003041984,0.003830429,0.9765252,0.0001067195],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.005896857,0.1541186,0.03707644,0.4438461,0.03567145,0.006620979,0.01667249,0.0007905973,0.2993065],"genre_scores_gemma":[0.1959723,0.2396059,0.2512021,0.1106499,0.005491099,0.00958812,0.04563657,0.0009373249,0.1409168],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.2589418,"threshold_uncertainty_score":0.5209335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03862375123776812,"score_gpt":0.3676532152096,"score_spread":0.3290294639718319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}