{"id":"W4408415307","doi":"10.3324/haematol.2024.287057","title":"Regulation of immune responses to therapeutic factor VIII by transplacental delivery of Fc-fused immunodominant factor VIII domains or peptides","year":2025,"lang":"en","type":"article","venue":"Haematologica","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Agence Nationale de la Recherche","keywords":"Transplacental; Immune tolerance; Immune system; Offspring; Immunology; Antibody; Von Willebrand factor; Fetus; Placenta; Biology; Pregnancy; Platelet; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000169038,0.0002126384,0.0001095976,0.00009070591,0.00006620822,0.0002083878,0.0001149264,0.0001909475,0.0007250365],"category_scores_gemma":[0.0001678842,0.00004859877,0.00009757136,0.00004545653,0.0002032077,0.0001099295,0.000140884,0.0004276498,0.0001241401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000129135,"about_ca_system_score_gemma":0.0001118408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001505021,"about_ca_topic_score_gemma":0.0001411048,"domain_scores_codex":[0.9998931,0.00004089028,0.000006206732,0.00002127537,0.00002005898,0.00001847465],"domain_scores_gemma":[0.9999173,0.00002695926,0.00002619858,0.00001143211,0.000006668654,0.0000114402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001715104,0.00008173753,0.0007597205,0.00003056984,0.000005934581,0.0002134651,0.00003558939,0.00007467078,0.9901966,0.0002534572,0.0000358317,0.008140971],"study_design_scores_gemma":[0.00005594377,0.003009849,0.01594926,0.00001571768,0.00004815991,0.003202482,0.00009248373,0.001140357,0.9693766,0.0001844095,0.006918967,0.000005746309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952565,0.001645333,0.00196033,0.0000424844,0.00001312305,0.00001745065,0.00002152403,0.00002634829,0.00101689],"genre_scores_gemma":[0.9974791,0.0006970831,0.0008304318,0.0000279935,0.000007968503,0.00001335562,0.00003429586,0.000006576377,0.0009032724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007250365,"threshold_uncertainty_score":0.002425492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0381505450178042,"score_gpt":0.3281099921600438,"score_spread":0.2899594471422396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}