{"id":"W4408418359","doi":"10.1038/s44259-025-00089-0","title":"Innovative perspectives on the discovery of small molecule antibiotics","year":2025,"lang":"en","type":"review","venue":"npj Antimicrobials and Resistance","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Antibiotics; Computational biology; Data science; Biology; Computer science; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003284553,0.0004234767,0.001721908,0.0001962725,0.0001385081,0.00006114284,0.000221402,0.0002899049,0.00001768548],"category_scores_gemma":[0.0005661868,0.0002162327,0.0003219054,0.0008500066,0.0004126696,0.00003458064,0.0001144944,0.0004788173,0.000003504706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000518411,"about_ca_system_score_gemma":0.0003647064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008333151,"about_ca_topic_score_gemma":0.000008762869,"domain_scores_codex":[0.9982771,0.0001544328,0.0005953292,0.0005995999,0.0001276471,0.0002459479],"domain_scores_gemma":[0.9982626,0.0003989513,0.0004678429,0.0005415035,0.0002982763,0.00003084799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00125879,0.002042065,0.00001249728,0.3759232,0.004490768,0.0002066376,0.001240396,2.109913e-7,0.1249843,0.1062174,0.1334693,0.2501544],"study_design_scores_gemma":[0.000345081,0.0001487047,0.00002061268,0.1213754,0.001381474,0.00002755683,0.0002384264,1.336995e-7,0.0524714,0.00004053774,0.8233862,0.0005644074],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007870484,0.9922754,0.00001217132,0.001349638,0.0001363496,0.001093426,0.0003605577,0.00001773782,0.003967708],"genre_scores_gemma":[0.00227451,0.9855661,0.0004956337,0.0003070574,0.0001376852,5.235535e-7,0.00003473807,0.00003054491,0.01115323],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6899169,"threshold_uncertainty_score":0.8817715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02461537726406977,"score_gpt":0.2867273005845705,"score_spread":0.2621119233205008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}