{"id":"W4408418359","doi":"10.1038/s44259-025-00089-0","title":"Innovative perspectives on the discovery of small molecule antibiotics","year":2025,"lang":"en","type":"review","venue":"npj Antimicrobials and Resistance","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Antibiotics; Computational biology; Data science; Biology; Computer science; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007399899,0.0008142418,0.001098985,0.002109435,0.0002887201,0.001279292,0.0008225858,0.001290065,0.004558632],"category_scores_gemma":[0.0007937302,0.0002576504,0.0006779691,0.001802585,0.0006598215,0.001903152,0.0008037079,0.002651211,0.001997947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006151238,"about_ca_system_score_gemma":0.001027499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005128671,"about_ca_topic_score_gemma":0.0009609753,"domain_scores_codex":[0.9996741,0.00006280781,0.00002845518,0.0000460378,0.0001477188,0.00004084484],"domain_scores_gemma":[0.9996254,0.0002209465,0.00003071328,0.00001326204,0.00007861248,0.00003095443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000114905,0.0001376201,0.0001330335,0.03219165,0.0001327176,0.0004438154,0.0001464285,0.0008084667,0.007921725,0.03588716,0.03482023,0.8872623],"study_design_scores_gemma":[0.00001886047,0.0001154564,0.0002932847,0.002791617,0.00005604883,0.0006256263,0.00005158096,0.0001268044,0.0007194208,0.006510555,0.9886762,0.0000144765],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001632614,0.9963169,0.0003117018,0.000503703,0.0004087614,0.000005317762,0.00001712763,0.00001024268,0.002262893],"genre_scores_gemma":[0.001067553,0.9973106,0.0002691519,0.0003710279,0.0002484338,0.000007126977,0.00002265893,0.000001595749,0.0007018009],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004558632,"threshold_uncertainty_score":0.01525009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02461537726406977,"score_gpt":0.2867273005845705,"score_spread":0.2621119233205008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}