{"id":"W4408421800","doi":"10.1093/braincomms/fcaf099","title":"Uncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer's disease","year":2025,"lang":"en","type":"article","venue":"Brain Communications","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Sherbrooke; Université de Montréal; Hôpital du Sacré-Cœur de Montréal; Toronto Metropolitan University; Montreal Neurological Institute and Hospital","funders":"Johnson and Johnson Pharmaceutical Research and Development; National Institute on Aging; Eisai Incorporated; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Pfizer Canada; GE Healthcare; Genentech; National Institutes of Health; H. Lundbeck A/S; Servier; Eisai; Alzheimer's Drug Discovery Foundation; Weston Brain Institute; Northern California Institute for Research and Education; McGill University; Alzheimer's Association; Fujirebio US; Pfizer; BioClinica; Biogen; Novartis Pharmaceuticals Corporation; Alzheimer Society; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Government of Canada; Merck; Janssen Biotech; Meso Scale Diagnostics; IXICO; Takeda Pharmaceutical Company; Janssen Alzheimer Immunotherapy Research And Development; AbbVie; Michael J. Fox Foundation for Parkinson's Research","keywords":"Atrophy; Disease; Alzheimer's disease; Pathology; Alzheimer's Disease Neuroimaging Initiative; Neuroimaging; Amyloid beta; Medicine; Neuroscience; Amyloid (mycology); Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003522819,0.0001070908,0.0001556789,0.0001796977,0.0003936217,0.00002108201,0.0004168575,0.00003445517,0.000007900409],"category_scores_gemma":[0.005055591,0.0001057165,0.00004474834,0.0004016254,0.0002520022,0.0001133027,0.001570313,0.0001636971,0.000005067409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004615685,"about_ca_system_score_gemma":0.00004685342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007586292,"about_ca_topic_score_gemma":0.0002200513,"domain_scores_codex":[0.9987307,0.0004548502,0.0002351927,0.0002761483,0.0001668612,0.0001362202],"domain_scores_gemma":[0.9936584,0.005183221,0.0001368943,0.0009478732,0.00002956289,0.00004405842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001087196,0.001142657,0.7334686,0.0001664612,0.000207678,0.000007045062,0.001936993,0.0008288339,0.06570984,0.1118627,0.00518073,0.07937969],"study_design_scores_gemma":[0.001314545,0.00009563546,0.8698198,0.0004246306,0.0001280582,0.000002635668,0.0002053794,0.004195531,0.02401346,0.0905355,0.008934374,0.0003304466],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9290544,0.004057474,0.003540972,0.05838145,0.0002235493,0.001303072,0.000383844,0.0001460015,0.002909199],"genre_scores_gemma":[0.9969019,0.0003628849,0.001063739,0.00145047,0.000004753887,0.0001365855,0.000007044138,0.000009185867,0.00006347761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1363512,"threshold_uncertainty_score":0.6052381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03813587621430343,"score_gpt":0.3153320043897375,"score_spread":0.277196128175434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}