{"id":"W4408421800","doi":"10.1093/braincomms/fcaf099","title":"Uncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer's disease","year":2025,"lang":"en","type":"article","venue":"Brain Communications","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Sherbrooke; Université de Montréal; Hôpital du Sacré-Cœur de Montréal; Toronto Metropolitan University; Montreal Neurological Institute and Hospital","funders":"Johnson and Johnson Pharmaceutical Research and Development; National Institute on Aging; Eisai Incorporated; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Pfizer Canada; GE Healthcare; Genentech; National Institutes of Health; H. Lundbeck A/S; Servier; Eisai; Alzheimer's Drug Discovery Foundation; Weston Brain Institute; Northern California Institute for Research and Education; McGill University; Alzheimer's Association; Fujirebio US; Pfizer; BioClinica; Biogen; Novartis Pharmaceuticals Corporation; Alzheimer Society; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Government of Canada; Merck; Janssen Biotech; Meso Scale Diagnostics; IXICO; Takeda Pharmaceutical Company; Janssen Alzheimer Immunotherapy Research And Development; AbbVie; Michael J. Fox Foundation for Parkinson's Research","keywords":"Atrophy; Disease; Alzheimer's disease; Pathology; Alzheimer's Disease Neuroimaging Initiative; Neuroimaging; Amyloid beta; Medicine; Neuroscience; Amyloid (mycology); Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003186736,0.0002181372,0.0001924105,0.001095736,0.0002583158,0.0003193238,0.0001769337,0.0002775347,0.0003712035],"category_scores_gemma":[0.0008148063,0.0001490281,0.0001834418,0.0005033958,0.0001804011,0.0002841257,0.0002609364,0.0002083665,0.00006584518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001633971,"about_ca_system_score_gemma":0.0001499437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01020152,"about_ca_topic_score_gemma":0.01436006,"domain_scores_codex":[0.999922,0.0000206996,0.00000676191,0.00002740254,0.00001178933,0.00001129891],"domain_scores_gemma":[0.999787,0.00004212928,0.00008354815,0.00002953848,0.00002984392,0.00002799017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004667515,0.00006466643,0.9762564,0.00002638385,0.0001125375,0.0003379984,0.0004997473,0.0003665406,0.0100312,0.00009299028,0.0001264675,0.01161834],"study_design_scores_gemma":[0.000002120162,0.0000464366,0.999188,0.000002411585,0.00001382952,0.0001408913,0.00008007663,0.0002404491,0.0001808448,0.00004789494,0.00005513894,0.000001947911],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994527,0.0001450461,0.0001662692,0.00001301315,6.13642e-7,0.000003878492,0.00008657661,0.00000493657,0.0001270454],"genre_scores_gemma":[0.9992606,0.0001213666,0.0003590255,0.000006879947,0.000002480956,0.00000461505,0.0001595267,0.00000153197,0.0000840044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01020152,"threshold_uncertainty_score":0.0202843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03813587621430343,"score_gpt":0.3153320043897375,"score_spread":0.277196128175434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}