{"id":"W4408423700","doi":"10.1126/sciadv.adr1719","title":"Senolytic treatment for low back pain","year":2025,"lang":"en","type":"article","venue":"Science Advances","topic":"Plant Toxicity and Pharmacological Properties","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Shriners Hospitals for Children - Canada; McGill University; McGill University Health Centre","funders":"","keywords":"Medicine; Spinal cord; Low back pain; Vanillin; Senescence; Inflammation; Internal medicine; Pharmacology; Pathology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001133845,0.0002429072,0.000348621,0.0004638636,0.0001834276,0.000123178,0.0002152909,0.0003538938,0.00297553],"category_scores_gemma":[0.00008087273,0.00006920164,0.0002632062,0.0002134963,0.0001321174,0.0001191553,0.0001428072,0.0005476724,0.0004000325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000907431,"about_ca_system_score_gemma":0.0001804707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003801095,"about_ca_topic_score_gemma":0.001207482,"domain_scores_codex":[0.999943,0.0000141145,0.000004760866,0.000006672865,0.00001590894,0.00001560867],"domain_scores_gemma":[0.9999628,0.000005893337,0.0000105539,0.000002857496,0.000007237973,0.00001057658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003709411,0.001664946,0.000797554,0.001651224,0.0001243621,0.000650038,0.00005781527,0.0001659636,0.7733927,0.0006019216,0.001847155,0.2153369],"study_design_scores_gemma":[0.00310485,0.06304214,0.05979688,0.001134891,0.0006902907,0.009313732,0.0003508331,0.002107694,0.6794615,0.001468001,0.1794372,0.00009197602],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7614249,0.2113241,0.007442728,0.001693887,0.0006216894,0.0004520321,0.0005855245,0.000540846,0.01591436],"genre_scores_gemma":[0.9229835,0.06016914,0.004706768,0.0006934797,0.0001797389,0.0001627588,0.000510644,0.00002064154,0.01057323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00297553,"threshold_uncertainty_score":0.009954095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02161491765814706,"score_gpt":0.316127807517988,"score_spread":0.2945128898598409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}