{"id":"W4408423700","doi":"10.1126/sciadv.adr1719","title":"Senolytic treatment for low back pain","year":2025,"lang":"en","type":"article","venue":"Science Advances","topic":"Plant Toxicity and Pharmacological Properties","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Shriners Hospitals for Children - Canada; McGill University; McGill University Health Centre","funders":"","keywords":"Medicine; Spinal cord; Low back pain; Vanillin; Senescence; Inflammation; Internal medicine; Pharmacology; Pathology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002533163,0.00006428972,0.00006236137,0.00002358132,0.0001616504,0.00002138026,0.0001726174,0.00002648034,0.00001393319],"category_scores_gemma":[0.0001097578,0.00004337006,0.00003173549,0.00009510964,0.0002702626,0.000008223771,0.00003150785,0.0000155728,0.0000105567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001682704,"about_ca_system_score_gemma":0.00009800471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001777876,"about_ca_topic_score_gemma":0.000007262847,"domain_scores_codex":[0.9994561,0.00001927844,0.00006813892,0.0002252805,0.00005013718,0.0001810353],"domain_scores_gemma":[0.9997967,0.00002987652,0.00001792034,0.00008888317,0.0000329992,0.00003361841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005698703,0.0000376313,0.0001281997,0.00002514411,0.0000051743,2.862267e-7,0.00000840815,0.0002901556,0.9577126,0.00007216502,0.0005278283,0.04113543],"study_design_scores_gemma":[0.0002136372,0.0002750922,0.0000537192,0.00001313219,0.00000292545,5.315229e-7,0.00003150164,0.0003897572,0.8393517,0.0004161835,0.1591893,0.00006251819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9634233,0.007738486,0.01646987,0.001293979,0.0006494139,0.0007191594,0.00005545478,0.0000279527,0.00962243],"genre_scores_gemma":[0.9914789,0.0003131549,0.001066882,0.0009843877,0.00004692566,0.00003867214,0.000009635442,0.000001820244,0.006059615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1586614,"threshold_uncertainty_score":0.176858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02161491765814706,"score_gpt":0.316127807517988,"score_spread":0.2945128898598409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}