{"id":"W4408444388","doi":"10.1016/j.lfs.2025.123562","title":"Metabolic reprogramming and synergistic cytotoxicity of genistein and chemotherapy in human breast cancer cells","year":2025,"lang":"en","type":"article","venue":"Life Sciences","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Cytotoxicity; Genistein; Reprogramming; Cancer research; Chemotherapy; Breast cancer; Human breast; Cancer; Chemistry; Oncology; Pharmacology; Medicine; Internal medicine; Biochemistry; Cell; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002824728,0.00008970754,0.0001759563,0.00007202604,0.00009318029,0.00002332235,0.0001223602,0.00005629023,0.000006873136],"category_scores_gemma":[0.0000228357,0.00007810313,0.00002756808,0.0002232921,0.000458802,0.000005526984,0.00006605228,0.00004024623,6.879282e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003135297,"about_ca_system_score_gemma":0.0001107281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007823228,"about_ca_topic_score_gemma":0.0003921897,"domain_scores_codex":[0.9992254,0.00003046358,0.0001632411,0.0003293887,0.00008632525,0.0001651888],"domain_scores_gemma":[0.9997209,0.000008789621,0.00006228012,0.0001301521,0.00002651775,0.00005130787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000018353,0.00002588386,0.01324811,0.00003096354,0.00001522881,1.388662e-7,0.00007329015,0.00001651309,0.9754537,0.0008100972,0.0001275298,0.01018016],"study_design_scores_gemma":[0.0008519021,0.00006988737,0.1454649,0.00005646339,0.00003193776,0.000003636819,0.0002509935,0.0000895389,0.833237,0.0003615884,0.0193788,0.0002033805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834961,0.01553947,0.00008284584,0.0002058869,0.0001891903,0.0001119148,0.00001514922,0.000004096372,0.0003553879],"genre_scores_gemma":[0.9953994,0.003481891,0.0003893391,0.0003113429,0.0001688546,0.00001615873,0.000001286284,0.000003784706,0.0002279695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1422167,"threshold_uncertainty_score":0.3184953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009541819744693003,"score_gpt":0.2844117818952297,"score_spread":0.2748699621505367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}