{"id":"W4408459293","doi":"10.1093/ofid/ofaf137","title":"Impact of Antibiotic Duration on Gut Microbiome Composition and Antimicrobial Resistance: A Substudy of the BALANCE Randomized Controlled Trial","year":2025,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada; Niagara Health System; Sunnybrook Health Science Centre; St. Michael's Hospital; Toronto Public Health; University of Toronto; Health Sciences Centre; University Health Network; Toronto General Hospital; McMaster University; Queen's University; Mount Sinai Hospital","funders":"Toronto General Hospital Research Institute, University Health Network; Canadian Institutes of Health Research; Physicians' Services Incorporated Foundation","keywords":"Microbiome; Randomized controlled trial; Medicine; Antibiotics; Antibiotic resistance; Bacteremia; Carriage; Internal medicine; Resistome; Antimicrobial; Gut flora; Microbiology; Biology; Immunology; Bioinformatics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008490496,0.00113466,0.004759369,0.0006840289,0.0008634647,0.001280798,0.0005661961,0.00176953,0.003884787],"category_scores_gemma":[0.01361056,0.0004893664,0.005136562,0.001043251,0.001026621,0.00156018,0.0006778377,0.001531368,0.0003389307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008094758,"about_ca_system_score_gemma":0.00123885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001593358,"about_ca_topic_score_gemma":0.002934133,"domain_scores_codex":[0.9924539,0.005319684,0.0008503021,0.0005799527,0.0004948361,0.0003013444],"domain_scores_gemma":[0.9917101,0.003710478,0.002528468,0.0007429431,0.0008351445,0.000472887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8826029,0.002105432,0.02255132,0.0127115,0.04464621,0.0001109806,0.0001612162,0.0005921306,0.002352526,0.0003928798,0.002694839,0.02907807],"study_design_scores_gemma":[0.7714489,0.07194585,0.07176121,0.004690415,0.06992813,0.0002035806,0.0001829461,0.001447321,0.001479123,0.001403199,0.005401765,0.0001075261],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8791232,0.1040564,0.002039037,0.001864048,0.001308927,0.004502846,0.004068505,0.0001276941,0.002909267],"genre_scores_gemma":[0.9811205,0.006727411,0.002048078,0.001220329,0.0007770407,0.005893775,0.001488944,0.00001712331,0.0007066479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008490496,"threshold_uncertainty_score":0.04490262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004057689073973988,"score_gpt":0.2828252333948405,"score_spread":0.2787675443208665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}