{"id":"W4408459343","doi":"10.1177/17588359251323985","title":"Immunotherapy in advanced, <i>KRAS</i> G12C-mutant non-small-cell lung cancer: current strategies and future directions","year":2025,"lang":"en","type":"review","venue":"Therapeutic Advances in Medical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"KRAS; Medicine; Cancer research; Blockade; Lung cancer; Cancer; Mutation; Immunotherapy; Mutant; Selumetinib; Oncology; Internal medicine; Biology; Colorectal cancer; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003363886,0.0006399882,0.002684184,0.0004814749,0.0001075829,0.00002449685,0.0002876971,0.0006567,0.000251445],"category_scores_gemma":[0.00002274081,0.0004589601,0.0002562008,0.0009276437,0.0002957831,0.0002017563,0.00007595059,0.001537359,0.000003777676],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001398004,"about_ca_system_score_gemma":0.006854212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008708786,"about_ca_topic_score_gemma":0.0009060685,"domain_scores_codex":[0.9968831,0.0003047944,0.001077402,0.0007657463,0.0003666282,0.0006023603],"domain_scores_gemma":[0.9982765,0.000687314,0.0003636963,0.0003870156,0.00006951808,0.0002160088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009261035,0.0006922992,0.0001767257,0.01189699,0.0002378825,0.0001470929,0.000547697,0.000004985942,9.036324e-7,0.000424773,0.00001894424,0.9857591],"study_design_scores_gemma":[0.00398223,0.0003202034,0.00007707172,0.0167865,0.001181004,0.00008052182,0.0006537507,0.00003237656,7.841655e-7,0.0003095963,0.9762309,0.0003450794],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005913904,0.988282,0.0002842473,0.001053745,0.002624096,0.002461515,0.0000469557,0.00005879453,0.005129477],"genre_scores_gemma":[0.00005929449,0.99555,0.0003708705,0.0006590605,0.0005822223,0.002417061,0.00009667712,0.00005716448,0.0002076208],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.985414,"threshold_uncertainty_score":0.9997862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01673988495437135,"score_gpt":0.4375702361328022,"score_spread":0.4208303511784309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}