{"id":"W4408466667","doi":"10.1021/acs.langmuir.4c05176","title":"The Interplay of Endosomal Escape and RNA Release from Polymeric Nanoparticles","year":2025,"lang":"en","type":"review","venue":"Langmuir","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Nanocarriers; RNA; Endosome; Endocytosis; Small interfering RNA; Internalization; Transfection; Chemistry; RNA interference; Cell biology; Biophysics; Biology; Drug delivery; Cell; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004308774,0.000161083,0.000355262,0.0000249816,0.00004989416,0.00002058431,0.0002376747,0.0001392016,0.00001029948],"category_scores_gemma":[0.00004218155,0.0001015838,0.0001587983,0.00005790661,0.0000795208,0.000001352766,0.0001765454,0.0000789211,0.000008315373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003675626,"about_ca_system_score_gemma":0.00006962948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005898596,"about_ca_topic_score_gemma":0.00002704666,"domain_scores_codex":[0.999276,0.00007761841,0.0002355968,0.0002259147,0.00005324691,0.0001316183],"domain_scores_gemma":[0.99949,0.00006059535,0.0001215371,0.00027718,0.00002116127,0.00002948876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002442275,0.00001565328,0.00001572955,0.0007429118,0.0001794503,0.000003785292,0.00001980493,3.168113e-8,0.01197109,0.0000353443,0.002124597,0.9848672],"study_design_scores_gemma":[0.0001087648,0.00009692681,0.0000269106,0.001446705,0.0002196078,0.000006847394,0.00004018347,0.000001460975,0.02155278,0.00001934026,0.9763253,0.0001552189],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01887331,0.9802021,0.000006791872,0.00002167993,0.0001245079,0.0001078836,0.0001171782,0.00000461841,0.0005419354],"genre_scores_gemma":[0.01432689,0.9842492,0.0000187969,0.0000476316,0.0001232014,0.00002431609,0.0001396501,0.0000115554,0.001058714],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9847119,"threshold_uncertainty_score":0.4142466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009067036941459173,"score_gpt":0.2836450502976721,"score_spread":0.2745780133562129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}