{"id":"W4408466667","doi":"10.1021/acs.langmuir.4c05176","title":"The Interplay of Endosomal Escape and RNA Release from Polymeric Nanoparticles","year":2025,"lang":"en","type":"review","venue":"Langmuir","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Nanocarriers; RNA; Endosome; Endocytosis; Small interfering RNA; Internalization; Transfection; Chemistry; RNA interference; Cell biology; Biophysics; Biology; Drug delivery; Cell; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003597756,0.0007212624,0.0007161092,0.001171831,0.0002197572,0.0007064477,0.0006187544,0.0009642756,0.001104349],"category_scores_gemma":[0.000253665,0.0003019958,0.0004031017,0.0008702998,0.000455398,0.001023316,0.0004823945,0.001037318,0.0009915659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006294418,"about_ca_system_score_gemma":0.0006368889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006765814,"about_ca_topic_score_gemma":0.0009444994,"domain_scores_codex":[0.9998482,0.00002111749,0.00001325202,0.00003253966,0.00006469321,0.00002012154],"domain_scores_gemma":[0.9998981,0.00005717145,0.00001545319,0.000003190693,0.00001925912,0.000006783391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005903916,0.0001033642,0.0002452224,0.02136389,0.00009771376,0.0004472212,0.0001161788,0.0008310368,0.04207594,0.0157023,0.009694614,0.9092634],"study_design_scores_gemma":[0.00001357324,0.0002384724,0.001071025,0.002290877,0.0001142276,0.002978449,0.0000860646,0.0003731797,0.03072243,0.003137905,0.9589306,0.00004315219],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008734955,0.9931717,0.001116496,0.0002614877,0.0001469103,0.00001368782,0.00001785918,0.00001652388,0.004381895],"genre_scores_gemma":[0.004221523,0.9921836,0.0009763829,0.000244273,0.00008624194,0.0000255725,0.00002589337,0.000004044378,0.00223246],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001171831,"threshold_uncertainty_score":0.004566908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009067036941459173,"score_gpt":0.2836450502976721,"score_spread":0.2745780133562129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}