{"id":"W4408477330","doi":"10.1016/j.jconrel.2025.113631","title":"Evaluation of focused ultrasound modulation of the blood-brain barrier in gray and white matter","year":2025,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"Alliance de recherche numérique du Canada; University of Toronto; Focused Ultrasound Foundation","keywords":"Gray (unit); Blood–brain barrier; White matter; White (mutation); Modulation (music); Neuroscience; Medicine; Chemistry; Psychology; Magnetic resonance imaging; Nuclear medicine; Physics; Radiology; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003793379,0.0004324401,0.0002222271,0.0002890365,0.0001429834,0.0001644327,0.0002234464,0.0003651389,0.0009118232],"category_scores_gemma":[0.0002506516,0.0001140559,0.0001511232,0.0001122572,0.0004592669,0.0002378747,0.0001155394,0.0003149276,0.0001501337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002876433,"about_ca_system_score_gemma":0.0002416008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009582201,"about_ca_topic_score_gemma":0.001053682,"domain_scores_codex":[0.9998695,0.00002542594,0.000007522069,0.00002758397,0.00004719005,0.00002276449],"domain_scores_gemma":[0.9998589,0.00002880197,0.00005300035,0.000009968733,0.00002819042,0.00002105544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000152367,0.00004753675,0.0002426228,0.0000519708,0.000004322472,0.00002105796,0.00001210394,0.00004310311,0.9975917,0.00003531718,0.00001580675,0.001782168],"study_design_scores_gemma":[0.00001798844,0.003509573,0.005802241,0.000006963286,0.00004197869,0.0001896814,0.00002595864,0.0005401438,0.9890171,0.00003080878,0.0008119027,0.000005530826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844566,0.003095183,0.01106335,0.0000723353,0.00002219316,0.0001709888,0.0001148973,0.00008792763,0.0009165403],"genre_scores_gemma":[0.9838871,0.002508488,0.01193713,0.00006382121,0.00002063637,0.0002537433,0.0002113338,0.00001536393,0.001102296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009582201,"threshold_uncertainty_score":0.003050387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005502288253331843,"score_gpt":0.2219546281777402,"score_spread":0.2164523399244084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}