{"id":"W4408486663","doi":"10.7555/jbr.38.20240394","title":"Upregulated inwardly rectifying K<sup>+</sup> current-mediated hypoactivity of parvalbumin interneurons underlies autism-like deficits in <i>Bod1</i>-deficient mice","year":2025,"lang":"en","type":"article","venue":"Journal of Biomedical Research","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"National Key Research and Development Program of China","keywords":"Hypoactivity; Parvalbumin; Interneuron; Downregulation and upregulation; Autism; Neuroscience; Chemistry; Endocrinology; Biology; Medicine; Biochemistry; Psychiatry; Gene; Inhibitory postsynaptic potential","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","sts","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.008840533,0.0006144534,0.001298833,0.005286147,0.0007144171,0.0003433158,0.003264082,0.0005087152,0.0002231972],"category_scores_gemma":[0.01880814,0.0005294857,0.000460041,0.009623924,0.004754439,0.0009380798,0.001901793,0.004819139,0.0001333122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007112936,"about_ca_system_score_gemma":0.002929986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002174657,"about_ca_topic_score_gemma":0.00003663033,"domain_scores_codex":[0.9822881,0.005329278,0.00229866,0.00158099,0.005931371,0.002571636],"domain_scores_gemma":[0.9867343,0.009649855,0.0007259976,0.0008228787,0.0008701546,0.001196811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001100237,0.002578296,0.0005411598,0.0002767126,0.00004067026,0.001254197,0.0004668213,0.0001036364,0.9690995,0.0004129993,0.00882568,0.01530013],"study_design_scores_gemma":[0.009596203,0.004898845,0.02745018,0.002442145,0.0001568115,0.001012232,0.0003412526,0.02989021,0.7937719,0.001620491,0.1275955,0.001224265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887099,0.00149927,0.0002410718,0.005311738,0.002332988,0.00095041,0.00008019186,0.00007601306,0.0007984294],"genre_scores_gemma":[0.9938987,0.004364821,0.00004829305,0.0003884985,0.0001466148,0.00004516687,0.000004426,0.00007030269,0.001033197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1753276,"threshold_uncertainty_score":0.9997157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09390953515189446,"score_gpt":0.4032705078006165,"score_spread":0.3093609726487221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}