{"id":"W4408491188","doi":"10.1172/jci186889","title":"Cellular and molecular features of asthma mucus plugs provide clues about their formation and persistence","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; University of California, San Francisco; National Institutes of Health; National Heart, Lung, and Blood Institute; Wallonie-Bruxelles International; Fonds Léon Fredericq","keywords":"Persistence (discontinuity); Asthma; Mucus; Biology; Computational biology; Medicine; Immunology; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000169552,0.000285491,0.0002593387,0.0008055439,0.0002537724,0.0005181531,0.0001972307,0.0005989213,0.001419324],"category_scores_gemma":[0.000166845,0.0001657809,0.0002679645,0.0002960869,0.0002550954,0.000372702,0.00030143,0.0003293213,0.0002639088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001776304,"about_ca_system_score_gemma":0.0001034186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003646363,"about_ca_topic_score_gemma":0.0004108593,"domain_scores_codex":[0.999863,0.00001387289,0.00001461933,0.00003031643,0.00003050398,0.00004760396],"domain_scores_gemma":[0.9998891,0.00001259053,0.00003691156,0.000009688146,0.00001566452,0.00003598268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002245528,0.00002751623,0.04328479,0.0001168664,0.00002252577,0.001001596,0.00007949817,0.00006715096,0.9506678,0.000187754,0.00007423879,0.004245741],"study_design_scores_gemma":[0.00002663644,0.0007222084,0.7472926,0.00006316704,0.0001030084,0.01310942,0.0006743182,0.001803797,0.2304303,0.0004797223,0.005273585,0.00002111356],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906419,0.005716156,0.002097222,0.0001029243,0.00001633358,0.00003705487,0.0005013914,0.00005629239,0.0008306629],"genre_scores_gemma":[0.9967789,0.000968874,0.001529578,0.00003308753,0.00002010005,0.00002289731,0.0003968333,0.000004858117,0.0002448987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001419324,"threshold_uncertainty_score":0.004748166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03432104884805522,"score_gpt":0.3308565048590822,"score_spread":0.296535456011027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}