{"id":"W4408495312","doi":"10.1101/2025.03.13.643017","title":"A Stochastic Mechanism Drives Fast Substrate Translocation in the AAA+ Machine ClpB","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Plant Genetic and Mutation Studies","field":"Agricultural and Biological Sciences","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation","keywords":"Millisecond; Chromosomal translocation; Computer science; Chemistry; Physics; Astronomy; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004778126,0.0003316705,0.0003400584,0.00005167369,0.0002128028,0.0001333011,0.0005356841,0.0002393685,0.00002639017],"category_scores_gemma":[0.00005317464,0.000141401,0.0001004623,0.0004965825,0.00006772632,0.00005195015,0.0001222025,0.0004089079,0.00001873153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004452813,"about_ca_system_score_gemma":0.00007825345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001891899,"about_ca_topic_score_gemma":0.0002410196,"domain_scores_codex":[0.9982669,0.0001810367,0.0003767575,0.0005626546,0.00028157,0.0003310977],"domain_scores_gemma":[0.9992485,0.0001913807,0.0001807554,0.0001732006,0.0001421929,0.00006395015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004635871,0.0002383527,0.002232035,0.0001199791,0.0001168709,0.00002565695,0.0001796657,0.0004730905,0.9917272,0.004576601,0.0001436467,0.0001205414],"study_design_scores_gemma":[0.000708153,0.0001460769,0.9165852,0.0008101313,0.000215673,7.376598e-8,0.0002690275,0.002769591,0.07534636,0.0001980122,0.001596634,0.00135504],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939123,0.001310302,0.001498354,0.00132986,0.0003794591,0.0007546432,0.0006681386,0.0001221423,0.00002481631],"genre_scores_gemma":[0.9986289,0.0004336614,0.0002251688,0.0003050233,0.0001593673,0.0002340589,0.000002864906,0.00000238019,0.00000862669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9163808,"threshold_uncertainty_score":0.5766166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0167249313868603,"score_gpt":0.2120910941642386,"score_spread":0.1953661627773783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}