{"id":"W4408498471","doi":"10.1128/spectrum.03318-24","title":"The GPCR antagonist PPTN synergizes with caspofungin providing increased fungicidal activity against <i>Aspergillus fumigatus</i>","year":2025,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Aspergillus fumigatus; Biology; Aspergillosis; Cryptococcus neoformans; Microbiology; Caspofungin; Voriconazole; Immunology; Antifungal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008970636,0.0003134401,0.0002949988,0.0001086063,0.0001227958,0.0001726863,0.0002197339,0.0002825769,0.002795306],"category_scores_gemma":[0.00009217636,0.00008569914,0.0002948137,0.00008019806,0.0001200845,0.0001523691,0.0001326156,0.0006385564,0.0006045201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002061709,"about_ca_system_score_gemma":0.0002189745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006966933,"about_ca_topic_score_gemma":0.00114543,"domain_scores_codex":[0.9998786,0.00002055631,0.0000120798,0.00001762596,0.00002817566,0.00004295808],"domain_scores_gemma":[0.9999647,0.000005548573,0.000006739517,0.000003867231,0.000004817347,0.00001428669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004891636,0.00009085816,0.0001018826,0.00006968111,0.00001113938,0.00005661972,0.00000606916,0.0001017033,0.9966474,0.00004618373,0.0003206835,0.002058513],"study_design_scores_gemma":[0.0001401351,0.002543757,0.00391143,0.00001061017,0.00003354873,0.0004214402,0.00002913475,0.0009784676,0.987623,0.00003014516,0.004269904,0.000008412801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889696,0.0027933,0.001618178,0.0004393877,0.0001898778,0.00008778971,0.00111344,0.0001924493,0.004595998],"genre_scores_gemma":[0.9941739,0.001077879,0.001429076,0.0001845615,0.0000414534,0.00005078769,0.001094703,0.00001158225,0.001936108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002795306,"threshold_uncertainty_score":0.009351254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004596848088909525,"score_gpt":0.2299295593274109,"score_spread":0.2253327112385013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}