{"id":"W4408498471","doi":"10.1128/spectrum.03318-24","title":"The GPCR antagonist PPTN synergizes with caspofungin providing increased fungicidal activity against <i>Aspergillus fumigatus</i>","year":2025,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Aspergillus fumigatus; Biology; Aspergillosis; Cryptococcus neoformans; Microbiology; Caspofungin; Voriconazole; Immunology; Antifungal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004911171,0.0003716922,0.0005923106,0.0001070347,0.0007752536,0.00006137056,0.0002677984,0.000246188,0.00004367268],"category_scores_gemma":[0.0001379969,0.0002266425,0.000228072,0.0004551546,0.000826673,0.00007632598,0.0001253207,0.0006090159,0.00004401405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003274933,"about_ca_system_score_gemma":0.000586212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003022352,"about_ca_topic_score_gemma":0.002808265,"domain_scores_codex":[0.9978668,0.0001930344,0.0003372984,0.0006889338,0.0001022521,0.0008116543],"domain_scores_gemma":[0.9985508,0.0003437138,0.0001285889,0.0007631801,0.00008739627,0.0001262971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003481788,0.0002000182,0.09960207,0.0001009104,0.0003625547,0.0001700443,0.00005200955,0.000003225404,0.8902037,0.001352634,0.003280901,0.001190205],"study_design_scores_gemma":[0.004035812,0.0009568055,0.1256403,0.0003712704,0.0004300085,0.0002796297,0.0006240879,0.00009841208,0.7853565,0.0001918279,0.08134819,0.0006671449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818038,0.001731075,0.0001953622,0.006498616,0.0003119701,0.0007137212,0.00007696167,0.0001663472,0.008502127],"genre_scores_gemma":[0.993121,0.0002431839,0.0001062412,0.001411673,0.0001202007,0.00002948301,0.00009045676,0.00002795622,0.004849792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1048472,"threshold_uncertainty_score":0.9242214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004596848088909525,"score_gpt":0.2299295593274109,"score_spread":0.2253327112385013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}