{"id":"W4408498891","doi":"10.1007/s00401-025-02863-w","title":"Biofluid-based staging of Alzheimer’s disease","year":2025,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute on Aging","keywords":"Concordance; Cerebrospinal fluid; Pathology; Stage (stratigraphy); Medicine; Disease; Alzheimer's disease; Cohort; Internal medicine; Oncology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003325284,0.0007965743,0.0005218631,0.002051936,0.0004275081,0.001759294,0.0005959489,0.0007751239,0.001237029],"category_scores_gemma":[0.005016626,0.0001680524,0.0003657678,0.0007778874,0.0006408286,0.001185405,0.0008370752,0.0005335751,0.000517726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005341104,"about_ca_system_score_gemma":0.0002284091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000813741,"about_ca_topic_score_gemma":0.0009315671,"domain_scores_codex":[0.9988588,0.0004339932,0.0001273552,0.0002761917,0.0002303457,0.0000733696],"domain_scores_gemma":[0.9987488,0.0003403644,0.0003983208,0.0001868187,0.0002802155,0.00004537963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003721158,0.000434522,0.677511,0.0009474772,0.000377511,0.0006521698,0.002124252,0.001775998,0.1108585,0.002085447,0.00225089,0.1972612],"study_design_scores_gemma":[0.0001148699,0.002115714,0.8662007,0.0005136649,0.0004515551,0.003710395,0.002273427,0.01321117,0.08950706,0.00854697,0.01315738,0.0001971058],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9650313,0.008297483,0.01904719,0.0004920438,0.0002034052,0.0001970079,0.001839381,0.0001428039,0.004749486],"genre_scores_gemma":[0.9819806,0.001525878,0.01392917,0.0001726596,0.00007796857,0.0001883471,0.001021325,0.00001552438,0.001088523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003325284,"threshold_uncertainty_score":0.01758599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02962090572482466,"score_gpt":0.3346667967176337,"score_spread":0.305045890992809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}