{"id":"W4408502173","doi":"10.1038/s42255-025-01237-6","title":"The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research","year":2025,"lang":"en","type":"review","venue":"Nature Metabolism","topic":"Diet and metabolism studies","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institute on Aging","keywords":"Reproducibility; Translation (biology); Computer science; Accounting; Chemistry; Statistics; Mathematics; Business; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.04802351,0.001378336,0.005472206,0.002529195,0.0003627296,0.004198087,0.003306355,0.002318335,0.002648342],"category_scores_gemma":[0.07922476,0.0006231412,0.00260908,0.003689856,0.0025573,0.005274905,0.002303068,0.003684203,0.0007540804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001426545,"about_ca_system_score_gemma":0.00474399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003873874,"about_ca_topic_score_gemma":0.005283952,"domain_scores_codex":[0.9856561,0.008000758,0.001427648,0.002142653,0.002546817,0.0002260313],"domain_scores_gemma":[0.8769654,0.09830815,0.007720938,0.007936628,0.008486336,0.0005824972],"domain_codex":null,"domain_gemma":"reproducibility","domain_candidate":"reproducibility","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0006466497,0.00007191132,0.004061374,0.03652009,0.005361214,0.0001028141,0.0004612351,0.001277891,0.001354434,0.01657504,0.01357945,0.919988],"study_design_scores_gemma":[0.0003633117,0.0008059868,0.04508678,0.04972864,0.01740583,0.001259657,0.0008837096,0.003481121,0.005250346,0.1826419,0.6925883,0.0005044701],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008277525,0.9876907,0.006189233,0.00252086,0.001636583,0.00002138501,0.0002586149,0.0000508103,0.0008040419],"genre_scores_gemma":[0.02840604,0.9451737,0.01659606,0.004581728,0.003485525,0.0001419391,0.0006293728,0.0001285926,0.0008569724],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9519765,"threshold_uncertainty_score":0.2539756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03090126989097714,"score_gpt":0.3972759461822061,"score_spread":0.366374676291229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}