{"id":"W4408519118","doi":"10.1038/s41416-025-02966-x","title":"Overall survival with maintenance olaparib in platinum-sensitive relapsed ovarian cancer by somatic or germline BRCA and homologous recombination repair mutation status","year":2025,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Merck Sharp and Dohme; Merck; AstraZeneca","keywords":"Olaparib; Medicine; BRCA mutation; Oncology; Ovarian cancer; Internal medicine; Germline mutation; Cohort; Cancer; Mutation; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00107567,0.0002614806,0.0005851218,0.0001899518,0.00009161798,0.0003818847,0.000295888,0.0002804903,0.001370583],"category_scores_gemma":[0.001077213,0.00009149652,0.0006417637,0.0002321162,0.0001945974,0.0003261443,0.0002404915,0.0006217625,0.0001043872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004512575,"about_ca_system_score_gemma":0.0003618344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002487188,"about_ca_topic_score_gemma":0.0006108426,"domain_scores_codex":[0.9997025,0.0001192168,0.00002465951,0.00006207044,0.00004929892,0.00004221601],"domain_scores_gemma":[0.999238,0.0002356843,0.0002903075,0.00006071768,0.00003596909,0.0001392976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5000731,0.002524155,0.1395402,0.001047658,0.002435787,0.0001989114,0.0001297894,0.004155556,0.01322058,0.0001630221,0.002914328,0.3335969],"study_design_scores_gemma":[0.1356529,0.231381,0.6060967,0.0003138619,0.003997715,0.002188047,0.0001055941,0.006334834,0.006389293,0.00105461,0.006423857,0.00006157211],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943022,0.004517618,0.0001631634,0.0001040747,0.00001656127,0.00005079259,0.0002967192,0.00001908632,0.000529778],"genre_scores_gemma":[0.9987104,0.0005497025,0.0000925347,0.00007086739,0.00002060888,0.00004373177,0.0004007632,0.000001910471,0.0001095646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001370583,"threshold_uncertainty_score":0.005688727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009865581849015198,"score_gpt":0.2956261631054802,"score_spread":0.285760581256465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}