{"id":"W4408526579","doi":"10.1186/s12936-025-05299-5","title":"Safety, tolerability and immunogenicity of a condensed, multi-dose prime regimen of PfSPZ Vaccine for the prevention of Plasmodium falciparum malaria infection","year":2025,"lang":"en","type":"article","venue":"Malaria Journal","topic":"Malaria Research and Control","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"ViTRAK Systems (Canada)","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Tolerability; Medicine; Malaria; Plasmodium falciparum; Adverse effect; Regimen; Malaria vaccine; Immunogenicity; Vaccination; Circumsporozoite protein; Immunology; Virology; Internal medicine; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001722989,0.0005427062,0.0006710278,0.0001996301,0.0001551409,0.0003012788,0.0004114372,0.0006753507,0.001252063],"category_scores_gemma":[0.001898409,0.0002704,0.0004385198,0.0001416798,0.0005804086,0.0004472833,0.0001886974,0.0008774616,0.0002312693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002805871,"about_ca_system_score_gemma":0.0003955335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002777377,"about_ca_topic_score_gemma":0.0002965842,"domain_scores_codex":[0.9993948,0.0003136876,0.00004657076,0.00008282152,0.0001013654,0.00006074412],"domain_scores_gemma":[0.9990801,0.0003090005,0.0002929625,0.00008538756,0.00007137161,0.0001612446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7138618,0.04784067,0.01390304,0.0008840875,0.0007364199,0.0001534682,0.0004455003,0.001771499,0.1106334,0.0001776818,0.0005997332,0.1089926],"study_design_scores_gemma":[0.0534688,0.9066807,0.02520526,0.00002845527,0.0002893008,0.0001703488,0.00004342284,0.0009758756,0.0125487,0.00008728629,0.0004878264,0.00001404623],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992684,0.0002567602,0.0001404036,0.00002955319,0.00001446074,0.0001208418,0.00004432488,0.000008210038,0.0001170646],"genre_scores_gemma":[0.9992982,0.0001325677,0.0002068164,0.00003969463,0.00002980996,0.00009496853,0.00006894508,0.000001681397,0.0001273026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001722989,"threshold_uncertainty_score":0.009112179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02114442823648403,"score_gpt":0.3175085843416457,"score_spread":0.2963641561051616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}