{"id":"W4408527527","doi":"10.3390/cells14060446","title":"The Role of Integrin β1D Mislocalization in the Pathophysiology of Calpain 3-Related Limb–Girdle Muscular Dystrophy","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Instituto de Salud Carlos III; Association Française contre les Myopathies","keywords":"Sarcolemma; Muscular dystrophy; Cell biology; Extracellular matrix; Sarcomere; Focal adhesion; Integrin-linked kinase; Calpain; Myocyte; Dysferlin; Integrin; Limb-girdle muscular dystrophy; Biology; Anatomy; Chemistry; Signal transduction; Kinase; Phenotype; Protein kinase A; Gene; Genetics; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002259509,0.00008420066,0.0001257088,0.00003068678,0.00004772766,0.00000277016,0.0002594583,0.0001528359,0.000007156672],"category_scores_gemma":[0.00007471317,0.00005218806,0.00008969582,0.0001566655,0.0002168108,0.000001287835,0.00006038354,0.00009397969,0.000002053038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003769209,"about_ca_system_score_gemma":0.00004665246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006094827,"about_ca_topic_score_gemma":0.00003111808,"domain_scores_codex":[0.9991677,0.0002666682,0.0002323915,0.0001574136,0.00004680647,0.0001290203],"domain_scores_gemma":[0.999467,0.00006590576,0.00008409218,0.0003247547,0.00004755464,0.00001071422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000126771,0.00009481631,0.0005185343,0.00002277308,0.0000330424,3.309758e-7,0.0001355505,0.0007123502,0.9928915,0.001707582,0.0003625053,0.003394228],"study_design_scores_gemma":[0.0007971898,0.0004865411,0.01026835,0.00003551747,0.00003358821,4.571607e-7,0.001830927,0.001163239,0.9523749,0.01658187,0.01628664,0.0001407444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946193,0.00264325,0.0003651233,0.0001079435,0.00009649635,0.0001726055,0.000006106234,0.000002703587,0.001986439],"genre_scores_gemma":[0.9991904,0.0004241236,0.00002419968,0.0001632351,0.00001270709,0.00001606964,0.00004119565,0.00000489156,0.0001232009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04051658,"threshold_uncertainty_score":0.2128167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001355872022216434,"score_gpt":0.1973613539536374,"score_spread":0.196005481931421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}