{"id":"W4408535380","doi":"10.1093/ofid/ofaf168","title":"Estimating the Age of Disease-causal HPV Infection Based on the Natural History of CIN2+ Among Females in Canada","year":2025,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Merck Canada Inc. (Canada)","funders":"Merck","keywords":"Medicine; Natural history; Cervical intraepithelial neoplasia; HPV infection; Vaccination; Disease; Demography; Cervical cancer; Human papillomavirus; Age groups; Young adult; HPV vaccines; Cancer; Gynecology; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001672277,0.0006414393,0.0005206962,0.0008722803,0.001100779,0.0008987876,0.001568904,0.0005541716,0.001564533],"category_scores_gemma":[0.007157402,0.0004496552,0.0009399578,0.0008530034,0.0005224984,0.000466808,0.0007021439,0.0007051334,0.0001674075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01988947,"about_ca_system_score_gemma":0.01655568,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9738448,"about_ca_topic_score_gemma":0.9561604,"domain_scores_codex":[0.999454,0.00009923666,0.0000225901,0.0002021692,0.00008574615,0.0001361781],"domain_scores_gemma":[0.9977664,0.000926437,0.0003184735,0.0001231717,0.0006716689,0.0001937769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003462835,0.0000619756,0.6845285,0.00007329084,0.0002334985,0.0001282165,0.00031577,0.3021305,0.0005102003,0.001107715,0.001093274,0.009470717],"study_design_scores_gemma":[0.0001048443,0.0001246378,0.2523386,0.00008338017,0.0002116905,0.0001351816,0.0005455412,0.7419623,0.0008790125,0.001370378,0.002175543,0.00006890712],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884836,0.0003542425,0.005845935,0.0002964437,0.000009104429,0.00009309085,0.003375623,0.00007097692,0.001471095],"genre_scores_gemma":[0.9939765,0.0002112558,0.003097203,0.00005305283,0.000002920695,0.00002901018,0.001971898,0.00001050907,0.0006476744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02615523,"threshold_uncertainty_score":0.1443089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0228630030403862,"score_gpt":0.3037949020825748,"score_spread":0.2809318990421886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}