{"id":"W4408541249","doi":"10.1038/s41573-025-01158-9","title":"Fibrosis: cross-organ biology and pathways to development of innovative drugs","year":2025,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Alcohol Abuse and Alcoholism; Leona M. and Harry B. Helmsley Charitable Trust; Canadian Institutes of Health Research; National Institute for Health and Care Research; National Institutes of Health; British Lung Foundation","keywords":"Drug development; Fibrosis; Drug discovery; Computational biology; Medicine; Organ system; Pharmacology; Biology; Drug; Bioinformatics; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008540438,0.0007540217,0.004802374,0.0005701152,0.000101761,0.00005837028,0.0003291879,0.001129593,0.00002663235],"category_scores_gemma":[0.0009814162,0.0004534962,0.0006579287,0.001904813,0.0001312105,0.0001092969,0.0003620695,0.001066145,0.00004183199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002275396,"about_ca_system_score_gemma":0.001951377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003755708,"about_ca_topic_score_gemma":0.000001220923,"domain_scores_codex":[0.9959212,0.0003154151,0.002195999,0.000905403,0.0002868953,0.0003750712],"domain_scores_gemma":[0.9974275,0.0003523894,0.0009915006,0.0007296731,0.0002921432,0.0002068549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002357046,0.0001044277,0.0001136301,0.111914,0.0004195162,0.000002715814,0.000377406,2.256423e-8,0.00002725198,0.0003395932,0.005239938,0.8814379],"study_design_scores_gemma":[0.0002835501,0.00002989865,0.0001213811,0.2715436,0.0006866343,0.00001112299,0.00005721888,3.08382e-8,0.00005567712,0.000009843475,0.7268947,0.0003063212],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003274542,0.9941761,0.00002158181,0.00004331445,0.0006366133,0.00341283,0.0003166392,0.00003716541,0.001028273],"genre_scores_gemma":[0.000176611,0.996071,0.0007529091,0.0004493709,0.0002144198,0.0004115717,0.0006067461,0.00005286371,0.001264442],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8811316,"threshold_uncertainty_score":0.9997917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0288697201987813,"score_gpt":0.3735030830447541,"score_spread":0.3446333628459728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}