{"id":"W4408543597","doi":"10.3390/ijms26062735","title":"A Metabolically Stable Apelin-13 Analog Acting as a Potent ITo Potassium Current Blocker with Potential Benefits for Brugada Syndrome","year":2025,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Pharmacology; Antagonist; Brugada syndrome; Potassium channel; Cardiac transient outward potassium current; Blockade; Chemistry; Patch clamp; Apelin; Medicine; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":{"n_in":0,"stratum":"aff_core","weight":5595.2375,"opus":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"Pharmacology study of an apelin-13 analog as a potassium current blocker for Brugada syndrome."},"gpt":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"It studies a potential cardiac drug analog for Brugada syndrome, not research practice."},"grok":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"Patch-clamp pharmacology of an apelin analog on cardiac currents; biomedical physiology."}},"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001268895,0.0002376557,0.0003087387,0.0001496649,0.0001264573,0.0001735547,0.0002529023,0.0003392712,0.0007278624],"category_scores_gemma":[0.0001572006,0.00007867506,0.0002044533,0.0001116214,0.0001675557,0.0002345226,0.000170346,0.0006206438,0.0001474921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008758898,"about_ca_system_score_gemma":0.0001100022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001453354,"about_ca_topic_score_gemma":0.0003133185,"domain_scores_codex":[0.9999216,0.0000190615,0.00001077826,0.00001331098,0.00001778463,0.00001760884],"domain_scores_gemma":[0.9999481,0.000009166849,0.00001389956,0.000006043037,0.000005083722,0.00001753473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004277873,0.00009433624,0.0003011849,0.00008502591,0.00001682796,0.0004436642,0.00001904306,0.00005129305,0.9914548,0.0001021645,0.00004492003,0.006959124],"study_design_scores_gemma":[0.000546959,0.01498016,0.02118148,0.00003368529,0.0002269519,0.006940398,0.00010657,0.001456657,0.9429922,0.0002298782,0.01126863,0.00003627924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988941,0.006620407,0.002866857,0.0001562917,0.00004948929,0.00003664854,0.00006752666,0.00004312558,0.001218664],"genre_scores_gemma":[0.9930952,0.002849466,0.003038837,0.0001399224,0.00003818847,0.00003253447,0.0001437248,0.00000793794,0.0006541073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007278624,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01775663413233038,"score_gpt":0.3460893116199579,"score_spread":0.3283326774876276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}