{"id":"W4408545865","doi":"10.51731/cjht.2025.1098","title":"Elexacaftor-Tezacaftor-Ivacaftor and Ivacaftor (Trikafta)","year":2025,"lang":"en","type":"article","venue":"Canadian Journal of Health Technologies","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Ivacaftor; Medicine; Internal medicine; Cystic fibrosis","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001657139,0.000391492,0.0007263993,0.001930783,0.000313125,0.001383212,0.0004649652,0.0004770406,0.007923306],"category_scores_gemma":[0.003251086,0.0001366268,0.001312302,0.001954343,0.0003354574,0.0006027734,0.0003048762,0.0006092631,0.001027947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003582368,"about_ca_system_score_gemma":0.00667597,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.05769718,"about_ca_topic_score_gemma":0.1944446,"domain_scores_codex":[0.9983844,0.0003655025,0.0002049378,0.0001007129,0.0008142359,0.0001302807],"domain_scores_gemma":[0.998351,0.0005498916,0.0003868273,0.00003425867,0.0005966823,0.00008142491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006880804,0.00006869019,0.002022389,0.02892558,0.0008750878,0.000226881,0.00009015594,0.0003874323,0.002273616,0.003877742,0.04631327,0.914251],"study_design_scores_gemma":[0.0003157207,0.0005273574,0.0117133,0.01830086,0.001399878,0.0009494461,0.0001363505,0.0001316097,0.001207844,0.0005726502,0.9647167,0.00002825007],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003946807,0.970917,0.0004262247,0.000998769,0.0002588489,0.0001803436,0.001448426,0.00004325924,0.02178038],"genre_scores_gemma":[0.04609205,0.9342482,0.002710942,0.001204008,0.0001752861,0.0001621753,0.001919049,0.00001792867,0.01347039],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9423028,"threshold_uncertainty_score":0.1147227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01667559881651378,"score_gpt":0.3309302250631296,"score_spread":0.3142546262466158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}