{"id":"W4408548332","doi":"10.1093/eurjpc/zwaf051","title":"Reassessing the association between age at menarche and cardiovascular disease: observational and Mendelian randomization analyses","year":2025,"lang":"en","type":"article","venue":"European Journal of Preventive Cardiology","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"School of Public Health, Portland State University; Health Data Research UK; Cambridge BHF Centre of Research Excellence; Institute of Human Nutrition, Columbia University; Novartis Portugal; NIHR Cambridge Biomedical Research Centre; Deutsche Krebshilfe; School of Public Health, Imperial College London; Economic and Social Research Council; Seventh Framework Programme; European Research Council; World Cancer Research Fund; Algemene Nederlandse Vereniging ter voorkoming van Blindheid; Ministerie van Volksgezondheid, Welzijn en Sport; Mutuelle Générale de l'Education Nationale; Compagnia di San Paolo; Austrian Science Fund; Institut Gustave-Roussy; Associazione Italiana per la Ricerca sul Cancro; Vetenskapsrådet; Cancerfonden; Instituto de Salud Carlos III; Sixth Framework Programme; ZonMw; European Commission; Engineering and Physical Sciences Research Council; Institut National de la Santé et de la Recherche Médicale; Health and Social Care Research and Development Division; Public Health Agency; Imperial College London; World Health Organization; Cancer Research UK; Wellcome Trust; Department of Epidemiology and Biostatistics, University of California, San Francisco; Chief Scientist Office, Scottish Government Health and Social Care Directorate; British Heart Foundation; Bundesministerium für Bildung und Forschung; Consiliul National al Cercetarii Stiintifice; Kræftens Bekæmpelse; UK Research and Innovation; Health Research; Deutsches Krebsforschungszentrum; Ligue Contre le Cancer; National Institute for Health and Care Research; Medical Research Council; Medical Research Council Canada; Department of Health and Social Care; Scottish Government; NIHR Imperial Biomedical Research Centre; Centre International de Recherche sur le Cancer","keywords":"Medicine; Mendelian randomization; Observational study; Hazard ratio; Stroke (engine); European Prospective Investigation into Cancer and Nutrition; Internal medicine; Proportional hazards model; Menarche; Myocardial infarction; Prospective cohort study; Confidence interval","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004689263,0.0001207063,0.000629538,0.0001438639,0.0001443872,0.00002680467,0.00007655085,0.00002924259,0.000003557697],"category_scores_gemma":[0.002316717,0.00008032119,0.0003293865,0.0001352908,0.000127689,0.0001034101,0.0001077701,0.000213169,0.000001078853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001285558,"about_ca_system_score_gemma":0.00008224259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001703984,"about_ca_topic_score_gemma":3.026586e-7,"domain_scores_codex":[0.9962143,0.002749819,0.0004155077,0.00022301,0.0002656168,0.0001316948],"domain_scores_gemma":[0.998463,0.0005231439,0.0003082623,0.0002076746,0.0004207822,0.00007709617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001237854,0.00002600459,0.9094055,0.00007899864,0.01978479,0.0004800892,0.0003118331,0.0006820535,0.0139628,0.0001449376,0.001467594,0.05241759],"study_design_scores_gemma":[0.004117954,0.00006427064,0.9789599,0.0001015052,0.003929934,0.00008271275,0.0000785451,0.00002956333,0.00009453446,0.0002828251,0.01219571,0.000062607],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9329175,0.03435495,0.02548608,0.003751989,0.0001914252,0.0003957589,0.00001111248,0.00001169279,0.002879518],"genre_scores_gemma":[0.996743,0.001324064,0.0004915607,0.00009251218,0.0005178089,0.00000248216,0.00001570113,0.00001228392,0.0008005585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0695544,"threshold_uncertainty_score":0.3275403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0717273840510418,"score_gpt":0.3286546780992781,"score_spread":0.2569272940482363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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