{"id":"W4408548332","doi":"10.1093/eurjpc/zwaf051","title":"Reassessing the association between age at menarche and cardiovascular disease: observational and Mendelian randomization analyses","year":2025,"lang":"en","type":"article","venue":"European Journal of Preventive Cardiology","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"School of Public Health, Portland State University; Health Data Research UK; Cambridge BHF Centre of Research Excellence; Institute of Human Nutrition, Columbia University; Novartis Portugal; NIHR Cambridge Biomedical Research Centre; Deutsche Krebshilfe; School of Public Health, Imperial College London; Economic and Social Research Council; Seventh Framework Programme; European Research Council; World Cancer Research Fund; Algemene Nederlandse Vereniging ter voorkoming van Blindheid; Ministerie van Volksgezondheid, Welzijn en Sport; Mutuelle Générale de l'Education Nationale; Compagnia di San Paolo; Austrian Science Fund; Institut Gustave-Roussy; Associazione Italiana per la Ricerca sul Cancro; Vetenskapsrådet; Cancerfonden; Instituto de Salud Carlos III; Sixth Framework Programme; ZonMw; European Commission; Engineering and Physical Sciences Research Council; Institut National de la Santé et de la Recherche Médicale; Health and Social Care Research and Development Division; Public Health Agency; Imperial College London; World Health Organization; Cancer Research UK; Wellcome Trust; Department of Epidemiology and Biostatistics, University of California, San Francisco; Chief Scientist Office, Scottish Government Health and Social Care Directorate; British Heart Foundation; Bundesministerium für Bildung und Forschung; Consiliul National al Cercetarii Stiintifice; Kræftens Bekæmpelse; UK Research and Innovation; Health Research; Deutsches Krebsforschungszentrum; Ligue Contre le Cancer; National Institute for Health and Care Research; Medical Research Council; Medical Research Council Canada; Department of Health and Social Care; Scottish Government; NIHR Imperial Biomedical Research Centre; Centre International de Recherche sur le Cancer","keywords":"Medicine; Mendelian randomization; Observational study; Hazard ratio; Stroke (engine); European Prospective Investigation into Cancer and Nutrition; Internal medicine; Proportional hazards model; Menarche; Myocardial infarction; Prospective cohort study; Confidence interval","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1383987,0.000857935,0.00232167,0.001458842,0.0007338578,0.001722464,0.00220788,0.001759639,0.001540005],"category_scores_gemma":[0.3104347,0.0008819011,0.003504847,0.002600919,0.001457352,0.001458783,0.001041052,0.00129038,0.0002573048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000810531,"about_ca_system_score_gemma":0.001296966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003474415,"about_ca_topic_score_gemma":0.001942809,"domain_scores_codex":[0.8087558,0.1673793,0.007027985,0.009731982,0.005987558,0.001117438],"domain_scores_gemma":[0.7568688,0.1642955,0.02686808,0.0463018,0.004875256,0.0007905843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02036361,0.000456971,0.7354932,0.002429842,0.05628042,0.00166986,0.002696008,0.01432396,0.003256389,0.03496504,0.005691635,0.122373],"study_design_scores_gemma":[0.007078683,0.008297401,0.6132807,0.000991917,0.03851274,0.005685566,0.0006507034,0.1953652,0.005420713,0.09823939,0.0259682,0.0005087673],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.620115,0.009478999,0.3597535,0.002312076,0.0005278522,0.00133653,0.0033288,0.001024459,0.002122747],"genre_scores_gemma":[0.9291216,0.0006349587,0.06731412,0.0005707974,0.0001225108,0.0007949612,0.0009288597,0.0001123761,0.0003998597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1383987,"threshold_uncertainty_score":0.7319309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0717273840510418,"score_gpt":0.3286546780992781,"score_spread":0.2569272940482363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}