{"id":"W4408550398","doi":"10.1038/s42003-025-07899-y","title":"A chromatin-focused CRISPR screen identifies USP22 as a barrier to somatic cell reprogramming","year":2025,"lang":"en","type":"article","venue":"Communications Biology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Reprogramming; Somatic cell; CRISPR; Chromatin; Cell biology; Biology; Cell; Computational biology; Genetics; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002217052,0.0005267471,0.0003990986,0.0003764279,0.0001547061,0.000481178,0.0002681784,0.0004760834,0.001751472],"category_scores_gemma":[0.0002019326,0.0001761163,0.0003133675,0.0001744565,0.000205352,0.0001371244,0.0003730107,0.0003878427,0.0004823674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002390328,"about_ca_system_score_gemma":0.0002118332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004139736,"about_ca_topic_score_gemma":0.000708758,"domain_scores_codex":[0.9998052,0.00002603194,0.00002204556,0.00004403694,0.00007664973,0.00002612424],"domain_scores_gemma":[0.9998154,0.00005840308,0.00004339267,0.00002347855,0.00001514284,0.00004419044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002358821,0.00000943337,0.0002280119,0.00001863784,0.000007046951,0.00009759861,0.000004025373,0.0000695037,0.998195,0.0001006678,0.00002465496,0.001221927],"study_design_scores_gemma":[0.000008341852,0.0001074586,0.003446943,0.000006815814,0.00003393637,0.0005018813,0.00001307067,0.001198755,0.9921764,0.0000616911,0.002438056,0.000006577172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9682569,0.001059107,0.02363574,0.0001441466,0.00003537444,0.0001061556,0.001752973,0.0007051729,0.004304422],"genre_scores_gemma":[0.9882812,0.0005622173,0.006568972,0.00009829308,0.000006158552,0.00003974954,0.001178797,0.00009261429,0.003171992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001751472,"threshold_uncertainty_score":0.005859315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02310832723885548,"score_gpt":0.3470582437043932,"score_spread":0.3239499164655377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}