{"id":"W4408550746","doi":"10.1002/bcp.70047","title":"Severe myelosuppression and alopecia after thiopurine initiation in a patient with <i>NUDT15</i> deficiency","year":2025,"lang":"en","type":"article","venue":"British Journal of Clinical Pharmacology","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; Health Sciences Centre; Western University; Sunnybrook Health Science Centre; London Health Sciences Centre; University of Toronto","funders":"","keywords":"Thiopurine methyltransferase; Medicine; Pharmacogenomics; Toxicity; Pharmacogenetics; Inflammatory bowel disease; Adverse effect; Allele; Disease; Internal medicine; Immunology; Pharmacology; Gene; Biology; Genotype; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002864898,0.000992867,0.0008255474,0.0009921716,0.001253831,0.0007885698,0.0005181293,0.002529435,0.001258234],"category_scores_gemma":[0.001370458,0.0005955742,0.0006916737,0.0006650159,0.0008943451,0.0006822454,0.0005678329,0.001945797,0.0003593265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009245864,"about_ca_system_score_gemma":0.0004217574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002742609,"about_ca_topic_score_gemma":0.003468738,"domain_scores_codex":[0.9996411,0.00005889467,0.0000422232,0.00009780211,0.00004926121,0.0001107943],"domain_scores_gemma":[0.9991528,0.0002704747,0.0001538701,0.0000434204,0.00003886126,0.0003405914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00009922748,0.0000535069,0.01058974,0.0000257425,0.00001326769,0.9835283,0.0004299583,0.0001395579,0.002667107,0.0001419347,0.0003139553,0.001997813],"study_design_scores_gemma":[0.00001823471,0.0002372728,0.01861453,0.00001586583,0.00002129925,0.9790615,0.0001373299,0.0003732354,0.0008056869,0.0001386366,0.0005615102,0.00001487483],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851591,0.001460818,0.001271241,0.003011604,0.0001446014,0.0001051461,0.0001442367,0.0001398458,0.008563382],"genre_scores_gemma":[0.9980488,0.0003004851,0.0003217696,0.0004631389,0.00009713956,0.000006180731,0.0000231305,0.00001298516,0.000726502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002742609,"threshold_uncertainty_score":0.006708384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01721696196852186,"score_gpt":0.3686765804017064,"score_spread":0.3514596184331846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}