{"id":"W4408555231","doi":"10.1055/s-0045-1804654","title":"Efficacy and Safety of Olomorasib with Pembrolizumab+Chemotherapy as First Line Treatment in Patients with KRAS G12C-Mutant Advanced NSCLC","year":2025,"lang":"en","type":"article","venue":"Pneumologie","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre; Alberta Health Services","funders":"","keywords":"Pembrolizumab; KRAS; Medicine; Chemotherapy; Oncology; Internal medicine; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007014799,0.000236581,0.000482306,0.0001390182,0.00004987834,0.000006737346,0.00007361796,0.00008460735,0.00004480505],"category_scores_gemma":[0.00003066343,0.0001421955,0.00004527466,0.0003452775,0.0001925869,0.00004381767,0.0000192729,0.0000964819,0.000001387005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002428362,"about_ca_system_score_gemma":0.0002048891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001844087,"about_ca_topic_score_gemma":0.0001741024,"domain_scores_codex":[0.9989455,0.00003018005,0.0002907717,0.0003328609,0.0001554242,0.0002452963],"domain_scores_gemma":[0.9993169,0.0001392002,0.0001068337,0.0003192517,0.00006730153,0.0000505666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1653166,0.001965538,0.6278624,0.0001445773,0.0005587987,0.00006705162,0.0004579442,0.00005870665,0.004217012,0.00004481517,0.00001636795,0.1992902],"study_design_scores_gemma":[0.05385742,0.009884818,0.9232596,0.0005669964,0.00008874724,0.00001343245,0.00007223345,0.000008911135,0.009411403,0.00002764362,0.002642531,0.000166322],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995064,0.0006706437,0.00002749756,0.001770627,0.00004823241,0.001158882,0.00001566432,0.00004018409,0.001204277],"genre_scores_gemma":[0.9976078,0.00138816,0.0002448717,0.0003986434,0.000009939639,0.00005154742,0.0000321759,0.00001871525,0.0002481356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2953972,"threshold_uncertainty_score":0.5798566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009384943681118335,"score_gpt":0.2713957310259564,"score_spread":0.2620107873448381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}