{"id":"W4408556535","doi":"10.1002/1878-0261.13820","title":"Targeting <scp>PRAME</scp> directly or via <scp>EZH2</scp> inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma","year":2025,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Retinoid; Cancer research; Retinoid X receptor beta; Retinoid X receptor alpha; Biology; Retinoid X receptor gamma; EZH2; Retinoid X receptor; Keratinocyte; Downregulation and upregulation; Retinoic acid; Cell culture; Nuclear receptor; Gene expression; Biochemistry; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006199791,0.000234708,0.0002096423,0.0001588625,0.000094282,0.0002266655,0.0001461825,0.0001817306,0.001344618],"category_scores_gemma":[0.00003668503,0.00005957998,0.0001211665,0.0001083733,0.0001574579,0.000187213,0.0001622295,0.000524945,0.0003432301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002220629,"about_ca_system_score_gemma":0.0001595326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003088359,"about_ca_topic_score_gemma":0.0008986279,"domain_scores_codex":[0.9999443,0.000005837082,0.000003115058,0.00001250919,0.00001979095,0.00001439937],"domain_scores_gemma":[0.9999832,0.000002021827,0.000004837324,0.00000277454,0.000002804741,0.000004254808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001300076,0.00004178449,0.0002060003,0.00006026126,0.000009219867,0.00006266795,0.000007197586,0.0001431887,0.9897416,0.0003189931,0.0002706761,0.009008417],"study_design_scores_gemma":[0.00003595447,0.0002996202,0.002981369,0.000004893495,0.00002180379,0.000383878,0.00001530697,0.0009426806,0.9821353,0.000103381,0.01307186,0.000004010519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9704911,0.01084149,0.009293605,0.0004796352,0.0001046531,0.00007949521,0.0005142516,0.0004361642,0.007759601],"genre_scores_gemma":[0.9877992,0.00291329,0.002032415,0.0001070245,0.00002026595,0.00003459058,0.0004491529,0.00002209623,0.006621932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001344618,"threshold_uncertainty_score":0.004498184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01297044067260604,"score_gpt":0.2751573793105292,"score_spread":0.2621869386379231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}