{"id":"W4408562027","doi":"10.1093/genetics/iyaf043","title":"Human MeCP2 binds to promoters and inhibits transcription in an unmethylated yeast genome","year":2025,"lang":"en","type":"article","venue":"Genetics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"MECP2; Biology; DNA methylation; Genetics; Histone methylation; Nucleosome; Histone; Promoter; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008540619,0.0001414755,0.0001039753,0.0001344347,0.00005962844,0.00003116235,0.0001251887,0.0001128662,0.000005596703],"category_scores_gemma":[0.00000591269,0.0001600209,0.00002280367,0.0001999776,0.00003755578,0.000002129139,0.00008232776,0.00006317863,0.000002993555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001203206,"about_ca_system_score_gemma":0.00003731016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007113098,"about_ca_topic_score_gemma":0.0003370317,"domain_scores_codex":[0.9990982,0.00004089172,0.0001909008,0.0003796233,0.00007479587,0.0002156102],"domain_scores_gemma":[0.9996549,8.42925e-7,0.00002112473,0.0002013655,0.00003290571,0.00008887472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001668351,0.00005813238,0.002899182,0.00001557857,0.00001033837,0.000001051007,0.0001802037,0.000245382,0.9933182,0.00001799162,0.00004651873,0.003190755],"study_design_scores_gemma":[0.0007917681,0.0004936315,0.4256843,0.0000202898,0.000012972,0.000002053906,0.0001381616,0.00005166631,0.5661924,0.0001560335,0.0061832,0.0002734875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984413,0.000400222,0.0002408771,0.0001740555,0.00006561104,0.0002960781,0.00001232865,0.000008474135,0.0003610539],"genre_scores_gemma":[0.99788,0.0001337161,0.001024031,0.0005053374,0.000009695625,0.00001992507,0.00008636221,0.00001806382,0.0003228903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4271258,"threshold_uncertainty_score":0.6525464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01021523300642186,"score_gpt":0.2574036298723464,"score_spread":0.2471883968659246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}