{"id":"W4408562027","doi":"10.1093/genetics/iyaf043","title":"Human MeCP2 binds to promoters and inhibits transcription in an unmethylated yeast genome","year":2025,"lang":"en","type":"article","venue":"Genetics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"MECP2; Biology; DNA methylation; Genetics; Histone methylation; Nucleosome; Histone; Promoter; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008465283,0.000360648,0.0002162171,0.000178899,0.0001259471,0.0002170337,0.0002499774,0.0001552524,0.001455647],"category_scores_gemma":[0.0001142595,0.0001837565,0.0001985882,0.0001462,0.0001621538,0.00006114713,0.0002466833,0.0003002938,0.0004911045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000342741,"about_ca_system_score_gemma":0.0002175975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00332999,"about_ca_topic_score_gemma":0.004456997,"domain_scores_codex":[0.9998832,0.00001701127,0.000009018741,0.00002484224,0.00004617478,0.00001980899],"domain_scores_gemma":[0.9999353,0.0000176356,0.000009109441,0.00001080461,0.000007606303,0.0000195462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005114559,0.00001317844,0.0001136377,0.00002289323,0.000006353882,0.00003249248,0.000007647815,0.0000787607,0.9988804,0.00004542939,0.00005805789,0.0006899041],"study_design_scores_gemma":[0.000008577595,0.00009607216,0.002307346,0.000004457587,0.000005488885,0.00009138611,0.00001080717,0.0008221144,0.9951425,0.00002275088,0.001486474,0.000002225278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898896,0.002704183,0.004139441,0.0001131037,0.00004541246,0.00001787916,0.0007565803,0.0002461731,0.002087752],"genre_scores_gemma":[0.9895598,0.001104058,0.002754415,0.00009305347,0.000008002697,0.00002690562,0.001572156,0.00006260705,0.004819027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00332999,"threshold_uncertainty_score":0.006621242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01021523300642186,"score_gpt":0.2574036298723464,"score_spread":0.2471883968659246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}