{"id":"W4408568173","doi":"10.1016/j.neurol.2025.01.248","title":"Efficacité et sécurité d’emploi de Tolebrutinib chez des patients atteints de sclérose en plaques secondairement progressive sans poussées : résultats de l’étude de phase 3 HERCULES","year":2025,"lang":"fr","type":"article","venue":"Revue Neurologique","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Gynecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002000313,0.0004055453,0.001531943,0.000306021,0.0002804769,0.0009251412,0.0002775037,0.0007656493,0.0022335],"category_scores_gemma":[0.00225029,0.0002707173,0.001213848,0.0003348103,0.0004302139,0.001020108,0.0001744335,0.001175154,0.000364859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007289189,"about_ca_system_score_gemma":0.0004507725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001394184,"about_ca_topic_score_gemma":0.001952615,"domain_scores_codex":[0.9992244,0.0002684587,0.00007272666,0.0001354069,0.0001623829,0.0001365543],"domain_scores_gemma":[0.9990144,0.0004323088,0.0002358422,0.00007447856,0.0001497758,0.00009322996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.240389,0.01182437,0.1295986,0.002206781,0.005893989,0.0009853903,0.001777997,0.004072866,0.08525357,0.000353026,0.003295629,0.5143487],"study_design_scores_gemma":[0.0524235,0.3313621,0.5377497,0.0005026176,0.009083634,0.003087839,0.0007198956,0.004181345,0.0377277,0.0005413007,0.02240254,0.0002177977],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885558,0.008578624,0.0003997287,0.0001545605,0.00004414673,0.0002013523,0.000654104,0.00001937279,0.00139218],"genre_scores_gemma":[0.9933028,0.002678099,0.0005725086,0.0003385886,0.00006706942,0.0003236756,0.001206647,0.00001691634,0.001493703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0022335,"threshold_uncertainty_score":0.01057881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01477677665752284,"score_gpt":0.3086872032269531,"score_spread":0.2939104265694303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}