{"id":"W4408568173","doi":"10.1016/j.neurol.2025.01.248","title":"Efficacité et sécurité d’emploi de Tolebrutinib chez des patients atteints de sclérose en plaques secondairement progressive sans poussées : résultats de l’étude de phase 3 HERCULES","year":2025,"lang":"fr","type":"article","venue":"Revue Neurologique","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Gynecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001647646,0.0007082016,0.0009542282,0.0002542616,0.0003057529,0.0001354589,0.0005199384,0.001151368,0.0003008715],"category_scores_gemma":[0.00346948,0.0006670903,0.0004247996,0.0004376518,0.0004986984,0.0001667956,0.0002273608,0.001333569,0.00005232907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008469461,"about_ca_system_score_gemma":0.00145357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002969087,"about_ca_topic_score_gemma":0.0001056104,"domain_scores_codex":[0.9931533,0.002820995,0.001039806,0.0009647047,0.0003116948,0.001709555],"domain_scores_gemma":[0.9965101,0.001365924,0.0004349621,0.0006254364,0.0002979817,0.0007655998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002530109,0.01044305,0.7846633,0.005344995,0.001307736,0.002549259,0.01674216,0.00131705,0.05030845,0.001007777,0.00582238,0.1179638],"study_design_scores_gemma":[0.01691775,0.005110467,0.8593591,0.02432787,0.002277292,0.0008579253,0.001792049,0.004825995,0.07452582,0.001333443,0.007467728,0.001204523],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9566578,0.03454077,0.0005827321,0.004144509,0.000688381,0.001820778,0.0002724422,0.0002958456,0.0009967721],"genre_scores_gemma":[0.9738041,0.01414422,0.001302538,0.008642815,0.0005958576,0.0004553923,0.00009834211,0.0001056778,0.0008511051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1167593,"threshold_uncertainty_score":0.9995781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01477677665752284,"score_gpt":0.3086872032269531,"score_spread":0.2939104265694303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}