{"id":"W4408572620","doi":"10.1016/j.xcrm.2025.101995","title":"BET inhibitor in combination with BCG vaccine enhances antitumor efficacy and orchestrates T cell reprogramming for melanoma","year":2025,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"","keywords":"Reprogramming; Cancer research; Melanoma; Medicine; Biology; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007831868,0.0002277085,0.0002251197,0.000169623,0.00007573088,0.000161549,0.00009571601,0.000139512,0.000845884],"category_scores_gemma":[0.0000441395,0.00008303528,0.0001974339,0.0001072082,0.0001034106,0.000110696,0.0001095344,0.0003955156,0.000228454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001104286,"about_ca_system_score_gemma":0.000160102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000212388,"about_ca_topic_score_gemma":0.0004735407,"domain_scores_codex":[0.9999413,0.00001050372,0.000005519111,0.000008780641,0.0000176876,0.00001626169],"domain_scores_gemma":[0.999983,0.000002436538,0.000004289212,0.000002123383,0.000001885351,0.000006316331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003394125,0.0001768607,0.0002575908,0.00005710442,0.000008203645,0.00002977275,0.000009390111,0.0002057934,0.9912135,0.00008224973,0.0001202069,0.007499956],"study_design_scores_gemma":[0.0001065601,0.001757675,0.003999379,0.00000676331,0.00005084228,0.0002494624,0.00001350392,0.002115628,0.9859504,0.0000619925,0.005682849,0.000004790631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927418,0.002938473,0.00190001,0.0001117303,0.00005395363,0.00005943986,0.000145229,0.00009291527,0.00195647],"genre_scores_gemma":[0.9949706,0.001359571,0.001445638,0.00008239914,0.00001226451,0.00004424959,0.0002327077,0.0000128492,0.00183975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000845884,"threshold_uncertainty_score":0.002829731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006313547182049755,"score_gpt":0.2515869090857489,"score_spread":0.2452733619036991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}