{"id":"W4408573863","doi":"10.1016/j.matt.2025.102043","title":"Personalized cervical plug combines mechanical and biological regulation for enhanced embryo implantation and live births","year":2025,"lang":"en","type":"article","venue":"Matter","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Key Research and Development Program of China; State Key Laboratory of Polymer Materials Engineering; Sichuan University; National Natural Science Foundation of China; Young Scientists Fund; Key Laboratory of Leather Chemistry and Engineering of Ministry of Education","keywords":"Embryo; Spark plug; Live birth; Computer science; Biology; Pregnancy; Engineering; Cell biology; Genetics; Mechanical engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002671079,0.0003397218,0.0002636322,0.0002953632,0.0002254539,0.0008330274,0.0003650603,0.0004601306,0.003052944],"category_scores_gemma":[0.0004375191,0.0001604607,0.000266125,0.0001398149,0.0003751054,0.0003306706,0.0005855408,0.000539004,0.0006187508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002229355,"about_ca_system_score_gemma":0.0002546789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001547749,"about_ca_topic_score_gemma":0.0003260029,"domain_scores_codex":[0.9997867,0.00003136749,0.000008968384,0.00004187587,0.00009134588,0.00003988388],"domain_scores_gemma":[0.9998068,0.00006067587,0.00005092676,0.000025849,0.00002550736,0.00003025583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000143056,0.00009724882,0.001047652,0.000127671,0.0000107279,0.0001507797,0.0000366808,0.0004397806,0.9785429,0.001227877,0.0003898019,0.01778583],"study_design_scores_gemma":[0.00005642126,0.001171007,0.01644554,0.00005019766,0.00007175509,0.001041927,0.0001517442,0.006963877,0.9532115,0.001181466,0.01961575,0.00003882898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9126142,0.008107968,0.06197007,0.001009126,0.0008316187,0.0001528,0.0005240469,0.0009650328,0.01382518],"genre_scores_gemma":[0.9832339,0.001408674,0.01043435,0.0002839473,0.0001576889,0.00007548527,0.0002316218,0.00007829072,0.004096002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003052944,"threshold_uncertainty_score":0.01021314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01279611571965843,"score_gpt":0.2563059771334589,"score_spread":0.2435098614138005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}