{"id":"W4408575838","doi":"10.1038/s12276-025-01423-2","title":"Orchestrating epigenetics: a comprehensive review of the methyltransferase SETD6","year":2025,"lang":"en","type":"review","venue":"Experimental & Molecular Medicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Israel Science Foundation; Natural Sciences and Engineering Research Council of Canada; Israel Cancer Association; Government of Canada; Israel Cancer Research Fund","keywords":"Chromatin; Epigenetics; Biology; Crosstalk; Histone; Methylation; Methyltransferase; Histone methyltransferase; DNA methylation; Transcription coregulator; Transcription factor; Regulation of gene expression; Chromatin remodeling; Histone methylation; Computational biology; Transcriptional regulation; Genetics; Cell biology; Gene expression; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003046147,0.0005375341,0.001413716,0.00008653372,0.00008042441,0.000007088215,0.0005792495,0.00031216,0.00007237886],"category_scores_gemma":[0.0002488501,0.0003629139,0.0006941456,0.0003974058,0.0002927495,0.000001727338,0.0002524896,0.0002786643,0.000002684828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000041371,"about_ca_system_score_gemma":0.0003982831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000254688,"about_ca_topic_score_gemma":0.000001022009,"domain_scores_codex":[0.9970505,0.0006362593,0.001016967,0.0005979431,0.000427265,0.0002711206],"domain_scores_gemma":[0.9982009,0.00007745548,0.0004403478,0.001016436,0.0001598945,0.0001049919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001118497,0.0001504868,0.000003180803,0.1142759,0.0005389263,0.00001629711,0.0001111235,0.000003880276,0.62489,0.0001558886,0.000599623,0.2592436],"study_design_scores_gemma":[0.0002951108,0.0003044255,0.000002005233,0.08116881,0.0006394777,0.000008940305,0.00003620153,6.645285e-7,0.2606678,0.00001263809,0.6565798,0.0002841212],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001649732,0.995993,0.0005143983,0.00009899168,0.0003772687,0.001457234,0.00004559599,0.000008359619,0.001340172],"genre_scores_gemma":[0.0003749852,0.9972836,0.0006161012,0.0007041536,0.000175651,0.0001580357,0.0004949636,0.00005643263,0.0001360708],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6559802,"threshold_uncertainty_score":0.9998823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03102979592381474,"score_gpt":0.3863079330462996,"score_spread":0.3552781371224848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}