{"id":"W4408592015","doi":"10.1101/2025.03.18.644000","title":"Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"","keywords":"Histopathology; Pancreas; Type 2 diabetes; Type (biology); Diabetes mellitus; Medicine; Pathology; Biology; Internal medicine; Endocrinology; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004120177,0.0001968463,0.0001405362,0.0008953779,0.0001703769,0.0006242933,0.0001109294,0.0002351381,0.001058134],"category_scores_gemma":[0.0001638401,0.0001871892,0.0001644405,0.0004112143,0.0002731211,0.0002088489,0.0003448762,0.0002839167,0.0003954336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000151548,"about_ca_system_score_gemma":0.0001288772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004941372,"about_ca_topic_score_gemma":0.0006805249,"domain_scores_codex":[0.9998884,0.0000210239,0.000007276253,0.00004119798,0.00002575965,0.00001635564],"domain_scores_gemma":[0.9998422,0.00002653707,0.00003839131,0.00003442941,0.00003352547,0.00002493136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002015744,0.00001380877,0.01629716,0.00008515635,0.00003121053,0.0001903043,0.0001388075,0.0004226815,0.9709446,0.0002295002,0.000199345,0.01124572],"study_design_scores_gemma":[0.00001535075,0.0002388278,0.5107152,0.00005684441,0.0001261911,0.004583539,0.000498869,0.004852775,0.4679388,0.001191347,0.009739392,0.00004286081],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741104,0.00280233,0.01878787,0.00008396457,0.00002457277,0.00002410995,0.001595673,0.0003201315,0.002250982],"genre_scores_gemma":[0.9744838,0.002348649,0.01941476,0.00008257615,0.00001675984,0.00002658288,0.001563282,0.00009774378,0.001965959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001058134,"threshold_uncertainty_score":0.003539801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008486821383768915,"score_gpt":0.2440933677846936,"score_spread":0.2356065464009247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}