{"id":"W4408592042","doi":"10.1158/1078-0432.ccr-24-0254","title":"Longitudinal Genomic Analysis to Fine-tune Targeted Therapy: Results of the Phase II LOGIC 2 Trial in Patients with <i>BRAF</i> V600-Mutant Metastatic Melanoma","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; McGill University; University of Toronto; Jewish General Hospital","funders":"Memorial Sloan-Kettering Cancer Center; Pfizer; National Cancer Institute; Foundation for the National Institutes of Health","keywords":"Medicine; Metastatic melanoma; Melanoma; Adverse effect; MEK inhibitor; Clinical endpoint; Internal medicine; Oncology; Phases of clinical research; Clinical trial; Cancer research; MAPK/ERK pathway; Kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001733017,0.00065389,0.0005944391,0.0001435173,0.0001895688,0.0005341017,0.0002907959,0.0004254757,0.001783395],"category_scores_gemma":[0.001227455,0.000216829,0.0006334326,0.0001650694,0.0003224137,0.0004283967,0.0002675241,0.001005659,0.0002220913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006632699,"about_ca_system_score_gemma":0.0007759487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007006808,"about_ca_topic_score_gemma":0.002011399,"domain_scores_codex":[0.9995882,0.0002628034,0.00001586445,0.00006664098,0.00002973975,0.00003670083],"domain_scores_gemma":[0.9993671,0.0001452468,0.0001955455,0.00004743175,0.0000427099,0.0002020468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7268178,0.01504123,0.06823248,0.0004228838,0.002695816,0.0001129146,0.0002138278,0.003805107,0.02220784,0.0002877096,0.005298393,0.154864],"study_design_scores_gemma":[0.4244434,0.3859653,0.1659691,0.00008108361,0.003053072,0.0004247873,0.000149317,0.006759707,0.005788046,0.000631449,0.006656038,0.00007876225],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957074,0.001530296,0.0004213079,0.0004323058,0.00004228588,0.0002528448,0.0006976024,0.00004702652,0.000868878],"genre_scores_gemma":[0.9953325,0.0006485116,0.0009622095,0.0005032044,0.00006235882,0.0003269391,0.001453411,0.00001158464,0.0006991383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001783395,"threshold_uncertainty_score":0.009165168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1079266029983788,"score_gpt":0.4474522176663169,"score_spread":0.3395256146679381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}