{"id":"W4408612249","doi":"10.1016/j.aquaculture.2025.742452","title":"Knockout of the fih gene by CRISPR/Cas9 enhances the hypoxia tolerance in grass carp (Ctenopharyngodon idella)","year":2025,"lang":"en","type":"article","venue":"Aquaculture","topic":"Physiological and biochemical adaptations","field":"Environmental Science","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dairy Farmers of Ontario","funders":"National Key Research and Development Program of China; Shanghai Ocean University; National Natural Science Foundation of China","keywords":"Grass carp; Biology; CRISPR; Gene; Hypoxia (environmental); Cas9; Hypoxia-inducible factors; Genetics; Cell biology; Fishery; Fish <Actinopterygii>; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009897957,0.0003868953,0.0002477976,0.0002926889,0.0002578439,0.0002546821,0.0003850106,0.0004526173,0.002294674],"category_scores_gemma":[0.0001038183,0.0002099752,0.0003378208,0.00010545,0.0004003288,0.0002585104,0.0004313074,0.0007019239,0.0003938595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002754306,"about_ca_system_score_gemma":0.0002698025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002501524,"about_ca_topic_score_gemma":0.004091227,"domain_scores_codex":[0.9998628,0.000005986002,0.00001014578,0.00004788544,0.00003494051,0.00003831686],"domain_scores_gemma":[0.9998665,0.0000107107,0.00004576648,0.00001110727,0.00001107931,0.00005476391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000598121,0.000009531881,0.0001314393,0.00002288211,0.000002895723,0.0000552959,0.00001622622,0.00003736751,0.9990514,0.00004473687,0.00003334685,0.0005350615],"study_design_scores_gemma":[0.00004695109,0.0003186104,0.0313389,0.00002071088,0.00006102659,0.000512256,0.0002038136,0.001916308,0.9605832,0.0001101355,0.004851443,0.00003665954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952454,0.0003046935,0.001905888,0.0001026974,0.00005758642,0.0000152398,0.000380711,0.0001423267,0.001845448],"genre_scores_gemma":[0.9875996,0.0001820934,0.0014579,0.00009999693,0.000009443545,0.00003163241,0.0003557649,0.00006766782,0.01019587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002501524,"threshold_uncertainty_score":0.007676423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006842541184843068,"score_gpt":0.2243197370079172,"score_spread":0.2174771958230741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}