{"id":"W4408612493","doi":"10.1042/bsr20241663","title":"Development and validation of an epigenetic signature of allostatic load","year":2025,"lang":"en","type":"article","venue":"Bioscience Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of British Columbia; Douglas Mental Health University Institute","funders":"Economic and Social Research Council; Biotechnology and Biological Sciences Research Council; Innosuisse - Schweizerische Agentur für Innovationsförderung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Age UK; Medical Research Council; Centre for Cognitive Ageing and Cognitive Epidemiology; Royal Society; Wellcome Trust; UK Research and Innovation; National Science Foundation","keywords":"Allostatic load; dNaM; Cohort; Epigenetics; DNA methylation; Confounding; Medicine; Oncology; Population; Cohort study; Bioinformatics; Internal medicine; Genetics; Biology; Physiology; Gene; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003961251,0.00006083777,0.00008513835,0.00004628108,0.0000340863,0.000007078702,0.0000549979,0.00006672012,0.000001730011],"category_scores_gemma":[0.0001456954,0.00005570998,0.00001672659,0.0001285958,0.00008631116,0.000003702834,0.00004569476,0.00001894722,5.887449e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008350094,"about_ca_system_score_gemma":0.0002841207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001009253,"about_ca_topic_score_gemma":0.00000935834,"domain_scores_codex":[0.9992433,0.00002158784,0.0002766675,0.0002234651,0.0001532761,0.000081681],"domain_scores_gemma":[0.9994562,0.000006232369,0.0001715328,0.0001991437,0.0001338077,0.0000330838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004759925,0.00003329707,0.006348584,0.0000299424,0.000005277706,0.000001542497,0.00008876714,0.00006066105,0.9835617,0.00002912124,0.000003503942,0.009832819],"study_design_scores_gemma":[0.00005523887,0.00007453318,0.03174976,0.00001987628,0.000006933428,0.000002255841,0.00003878486,0.00003529044,0.9657455,0.0002711156,0.00194587,0.00005483418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994785,0.001176353,0.003403731,0.00001668552,0.00008914248,0.0001041309,0.000001220701,0.000002261917,0.0004214407],"genre_scores_gemma":[0.9902127,0.00008184125,0.009534498,0.00001318227,0.000006721849,0.000003391812,0.0000159,0.000002746379,0.0001290014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02540118,"threshold_uncertainty_score":0.2271787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009551035435881901,"score_gpt":0.2742048314527805,"score_spread":0.2646537960168986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}