{"id":"W4408634032","doi":"10.1016/j.diabres.2025.112098","title":"Serum Neurofilament Light Chain and Structural and Functional Nerve Fiber Loss in Painful and Painless Diabetic Polyneuropathy","year":2025,"lang":"en","type":"article","venue":"Diabetes Research and Clinical Practice","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Steno Diabetes Center Aarhus; Horizon 2020; Fonden til Lægevidenskabens Fremme; Medical Research Council; Wörwag Pharma; TrigoCare International; Mitsubishi Tanabe Pharma Corporation; Versus Arthritis; Riisfort Fonden; Diabetesforeningen; Astellas Pharma; Novo Nordisk; Novo Nordisk Fonden; Academy of Medical Sciences; Nevro; Danish Diabetes Academy; A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal; Procter and Gamble; Biotechnology and Biological Sciences Research Council; Wellcome Trust; Abbott Laboratories; Aarhus Universitetshospital; Harvard University; Pfizer; Biogen; Imperial College London; Sanofi; University of the Witwatersrand, Johannesburg; European Commission; Horizon 2020 Framework Programme; Aarhus Universitet; European Foundation for the Study of Diabetes; UK Research and Innovation; AstraZeneca","keywords":"Medicine; Diabetes mellitus; Polyneuropathy; Diabetic neuropathy; Internal medicine; Endocrinology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003264353,0.0001831087,0.0003832879,0.0001833568,0.000212081,0.0001221274,0.00004749198,0.0001433882,0.00003440626],"category_scores_gemma":[0.006055441,0.0001430683,0.00003535255,0.0002665854,0.0003690939,0.0002199036,0.0002856006,0.0008157663,0.000005251247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002956049,"about_ca_system_score_gemma":0.00008428844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003739,"about_ca_topic_score_gemma":0.000009572468,"domain_scores_codex":[0.9969932,0.00110112,0.0004057705,0.0006088321,0.0003800094,0.0005110521],"domain_scores_gemma":[0.9932709,0.005870469,0.00006868449,0.000222149,0.0001914169,0.0003763296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006553507,0.0004128012,0.9282634,0.0002574523,0.0001882458,0.0003593407,0.00008209367,2.033551e-7,0.0007013759,0.001079361,0.0003016753,0.0676987],"study_design_scores_gemma":[0.003668366,0.001633371,0.985966,0.0001751607,0.000104402,0.00002435286,0.0003068988,0.001185812,0.0003171897,0.002680563,0.00380311,0.0001347554],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97851,0.003266629,0.000004769571,0.01698966,0.00009315299,0.0005050526,0.00001180007,0.00001616927,0.0006027214],"genre_scores_gemma":[0.9948709,0.00156661,0.000238106,0.002257961,0.00008420632,0.00003420514,0.00001145603,0.00001558122,0.0009209644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06756394,"threshold_uncertainty_score":0.7249367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04498195787603037,"score_gpt":0.4014563459876431,"score_spread":0.3564743881116127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}