{"id":"W4408634032","doi":"10.1016/j.diabres.2025.112098","title":"Serum Neurofilament Light Chain and Structural and Functional Nerve Fiber Loss in Painful and Painless Diabetic Polyneuropathy","year":2025,"lang":"en","type":"article","venue":"Diabetes Research and Clinical Practice","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Steno Diabetes Center Aarhus; Horizon 2020; Fonden til Lægevidenskabens Fremme; Medical Research Council; Wörwag Pharma; TrigoCare International; Mitsubishi Tanabe Pharma Corporation; Versus Arthritis; Riisfort Fonden; Diabetesforeningen; Astellas Pharma; Novo Nordisk; Novo Nordisk Fonden; Academy of Medical Sciences; Nevro; Danish Diabetes Academy; A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal; Procter and Gamble; Biotechnology and Biological Sciences Research Council; Wellcome Trust; Abbott Laboratories; Aarhus Universitetshospital; Harvard University; Pfizer; Biogen; Imperial College London; Sanofi; University of the Witwatersrand, Johannesburg; European Commission; Horizon 2020 Framework Programme; Aarhus Universitet; European Foundation for the Study of Diabetes; UK Research and Innovation; AstraZeneca","keywords":"Medicine; Diabetes mellitus; Polyneuropathy; Diabetic neuropathy; Internal medicine; Endocrinology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007987025,0.0003220955,0.0003007095,0.0007437309,0.0002470587,0.0004828709,0.0002793145,0.0004385463,0.001560452],"category_scores_gemma":[0.001837413,0.0001955149,0.0003535646,0.0006233075,0.0002073674,0.0003852941,0.0003374905,0.0003460553,0.0001935951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002271666,"about_ca_system_score_gemma":0.0001345617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002209162,"about_ca_topic_score_gemma":0.00273423,"domain_scores_codex":[0.9996841,0.00006899855,0.00004155357,0.0001078352,0.00006191369,0.00003550149],"domain_scores_gemma":[0.9990624,0.0001143298,0.0005408796,0.00005442021,0.00009876733,0.0001293408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002823791,0.00003068441,0.9979368,0.00002075542,0.0001082162,0.00003954932,0.00002137811,0.00003280149,0.0005543493,0.000006911974,0.0000314981,0.0009346516],"study_design_scores_gemma":[0.000007963746,0.00008145322,0.9994156,0.000006352147,0.00003431057,0.000210902,0.00002559598,0.00008583802,0.00007582601,0.00001455383,0.00003993434,0.000001645356],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988889,0.0004817397,0.00008374347,0.00001843601,0.000003637487,0.000005284367,0.0003319379,0.000003115589,0.0001831073],"genre_scores_gemma":[0.9994224,0.00009704503,0.00009022409,0.00001894156,0.000005937839,0.000005141796,0.0002391563,9.565746e-7,0.0001200602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002209162,"threshold_uncertainty_score":0.005220234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04498195787603037,"score_gpt":0.4014563459876431,"score_spread":0.3564743881116127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}