{"id":"W4408634802","doi":"10.1016/j.coph.2025.102522","title":"Balancing genome integrity and carcinogenesis: Insights into DNA damage response, repair pathways, and cancer therapies","year":2025,"lang":"en","type":"editorial","venue":"Current Opinion in Pharmacology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Board of Research in Nuclear Sciences; Science and Engineering Research Board; National Science Foundation; National Institutes of Health; Indo-French Centre for the Promotion of Advanced Research; Council of Scientific and Industrial Research, India; Department of Biotechnology, Ministry of Science and Technology, India","keywords":"DNA damage; DNA repair; Carcinogenesis; Genome; Biology; DNA Damage Repair; Cancer; Genome instability; Computational biology; DNA; Cancer research; Genetics; Bioinformatics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006938504,0.003123785,0.002884164,0.002036159,0.001804597,0.006090022,0.003545789,0.01241252,0.01121562],"category_scores_gemma":[0.01294834,0.0009340254,0.001862631,0.000911527,0.002315831,0.004025161,0.001364754,0.02092236,0.007832921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002984002,"about_ca_system_score_gemma":0.002586339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001208957,"about_ca_topic_score_gemma":0.004354399,"domain_scores_codex":[0.9968894,0.0005839747,0.0002998548,0.0003556507,0.001625604,0.000245518],"domain_scores_gemma":[0.9898192,0.003856964,0.0005796498,0.0002402437,0.003668941,0.001835056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007942229,0.00002100986,0.00001848531,0.0003513828,0.0000246936,0.00008917875,0.000008908657,0.00003144535,0.0001670801,0.0007496295,0.9890262,0.009432458],"study_design_scores_gemma":[0.00009116322,0.00005164756,0.0002329978,0.0003392216,0.00006720486,0.0001968895,0.00002637828,0.000180205,0.0001992919,0.002019611,0.9965759,0.00001948919],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.00004873212,0.01985367,0.0001877654,0.03579739,0.9421005,0.00002336969,0.00005569031,0.00004596201,0.00188688],"genre_scores_gemma":[0.0005066538,0.01312967,0.0001573729,0.01827519,0.9584765,0.00002002245,0.00002997536,0.00001889794,0.009385624],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.01241252,"threshold_uncertainty_score":0.03751999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02178130921708538,"score_gpt":0.3387386509176078,"score_spread":0.3169573417005224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}