{"id":"W4408635966","doi":"10.3389/fmed.2025.1557611","title":"Localization of fluorescent gold nanoparticles throughout the eye after topical administration","year":2025,"lang":"en","type":"article","venue":"Frontiers in Medicine","topic":"Ocular Surface and Contact Lens","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Health Research","keywords":"Biocompatibility; Colloidal gold; Drug delivery; Cornea; Fluorescence; Nanotechnology; Nanoparticle; Ex vivo; Systemic administration; Bioavailability; Chemistry; Biophysics; In vivo; Biomedical engineering; Materials science; Pharmacology; Medicine; Ophthalmology; In vitro; Biochemistry; Biology; Biotechnology; Optics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000328079,0.0003068899,0.0001962449,0.0003205919,0.0001797178,0.0002819424,0.0001919561,0.0003900612,0.0003490015],"category_scores_gemma":[0.0002409523,0.0001879685,0.0002310295,0.0001418672,0.0002893426,0.0001979768,0.0001610211,0.0002391057,0.0001899736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004733871,"about_ca_system_score_gemma":0.0002175382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002923784,"about_ca_topic_score_gemma":0.003222546,"domain_scores_codex":[0.999826,0.00002767644,0.000009816762,0.00007135165,0.00003391432,0.00003119237],"domain_scores_gemma":[0.9998699,0.000038098,0.00003000081,0.0000200584,0.00002847621,0.00001336844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002061212,0.000005096936,0.00009894958,0.00002275259,0.000002501958,0.00003223219,0.00002409681,0.00004453199,0.9988196,0.00004422164,0.00001132099,0.0008741223],"study_design_scores_gemma":[0.000003598547,0.0001552719,0.001259685,0.000004438806,0.00001014062,0.00007246083,0.00001786733,0.0004595958,0.9974356,0.00001774975,0.0005602714,0.000003470767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790876,0.002786255,0.01411258,0.00009398485,0.00003666043,0.00008209663,0.0001345747,0.0001004465,0.00356578],"genre_scores_gemma":[0.985479,0.0009714618,0.01008331,0.00007167357,0.00001004375,0.00003961317,0.0001052573,0.00002909993,0.003210636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002923784,"threshold_uncertainty_score":0.005813539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008941895080743454,"score_gpt":0.2938546555059859,"score_spread":0.2849127604252425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}