{"id":"W4408648064","doi":"10.3389/frtra.2025.1514956","title":"From Edmonton to Lantidra and beyond: immunoengineering islet transplantation to cure type 1 diabetes","year":2025,"lang":"en","type":"review","venue":"Frontiers in Transplantation","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Immunosuppression; Islet; Transplantation; Medicine; Type 1 diabetes; Islet cell transplantation; Immunology; Pancreatic islets; Immune system; Insulin; Diabetes mellitus; Bioinformatics; Biology; Internal medicine; Endocrinology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005758404,0.0007212303,0.0006783718,0.001326759,0.0002658551,0.001320522,0.0006340336,0.001250894,0.006566103],"category_scores_gemma":[0.0004213634,0.0002052808,0.000610629,0.000793981,0.0005632333,0.001558369,0.000888275,0.002381112,0.003709101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007051831,"about_ca_system_score_gemma":0.0006272048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007225106,"about_ca_topic_score_gemma":0.001145416,"domain_scores_codex":[0.9997738,0.00004834211,0.00001711661,0.00004919929,0.00007875149,0.00003276054],"domain_scores_gemma":[0.9998108,0.00006980195,0.0000221601,0.00001068945,0.00005147757,0.00003512431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001813048,0.0001544713,0.0003065849,0.007882415,0.00008017731,0.000732217,0.0004635165,0.0004078343,0.02402959,0.0305713,0.1257715,0.8094192],"study_design_scores_gemma":[0.000008460152,0.0001138285,0.0003101664,0.0009786703,0.00002576658,0.0007535242,0.00005891328,0.00006392336,0.002442985,0.002824615,0.9924005,0.00001866989],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001745989,0.9728119,0.001894215,0.00388057,0.003853533,0.00002147841,0.00004321983,0.00008449227,0.01566455],"genre_scores_gemma":[0.008763005,0.9579223,0.002519283,0.006103577,0.002511154,0.00003821479,0.0001067697,0.00007060574,0.02196498],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006566103,"threshold_uncertainty_score":0.0219658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009132498035172087,"score_gpt":0.2660254966849037,"score_spread":0.2568929986497316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}