{"id":"W4408648064","doi":"10.3389/frtra.2025.1514956","title":"From Edmonton to Lantidra and beyond: immunoengineering islet transplantation to cure type 1 diabetes","year":2025,"lang":"en","type":"review","venue":"Frontiers in Transplantation","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Immunosuppression; Islet; Transplantation; Medicine; Type 1 diabetes; Islet cell transplantation; Immunology; Pancreatic islets; Immune system; Insulin; Diabetes mellitus; Bioinformatics; Biology; Internal medicine; Endocrinology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001466819,0.0004055696,0.001344741,0.000874098,0.00004437596,0.00003993625,0.0001053983,0.0003077767,0.00003331821],"category_scores_gemma":[0.00004914154,0.0003831442,0.000136195,0.0007277729,0.00001728617,0.0001145606,0.000007963722,0.0002934809,0.00002511012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001078276,"about_ca_system_score_gemma":0.000130625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006642076,"about_ca_topic_score_gemma":0.00001230432,"domain_scores_codex":[0.9983287,0.00008046942,0.0005504745,0.0005076507,0.0002188308,0.0003138853],"domain_scores_gemma":[0.9992878,0.0001880528,0.00007462492,0.0002336136,0.0000466787,0.0001692585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005935135,0.0001077841,0.001909525,0.07226539,0.0006642286,0.0001232043,0.003548309,0.0001100019,0.0005100837,0.00004598646,0.0121607,0.9079612],"study_design_scores_gemma":[0.005020097,0.0008566607,0.005842669,0.1379809,0.01272653,0.00005085099,0.0005998124,0.0004494005,0.0009464872,0.0002145352,0.8332305,0.002081497],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00388708,0.980566,0.01026982,0.00017813,0.00185736,0.00152416,0.0006167657,0.0001101174,0.0009905553],"genre_scores_gemma":[0.0002184989,0.9824234,0.01277725,0.0003278355,0.0001731422,0.000166927,0.00357437,0.00004539893,0.0002932089],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9058798,"threshold_uncertainty_score":0.9998621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009132498035172087,"score_gpt":0.2660254966849037,"score_spread":0.2568929986497316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}