{"id":"W4408648268","doi":"10.2147/jir.s500822","title":"FLI1 Induces Plaque Psoriasis and Its Inhibition Attenuates Disease Progression","year":2025,"lang":"en","type":"article","venue":"Journal of Inflammation Research","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Plaque psoriasis; Psoriasis; FLI1; Disease; Medicine; Cancer research; Immunology; Internal medicine; Biology; Genetics; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001280159,0.00009772328,0.0001760704,0.0006159322,0.0002911961,0.0000492825,0.0001031329,0.0001489168,0.0001024813],"category_scores_gemma":[0.0005555963,0.00007220301,0.0000612509,0.0003196913,0.0000855026,0.0002943042,0.00006867198,0.0003162366,0.00006320708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006289223,"about_ca_system_score_gemma":0.0002028891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003274967,"about_ca_topic_score_gemma":0.000003475756,"domain_scores_codex":[0.998612,0.0005241985,0.000386532,0.0001306393,0.0001364105,0.0002102526],"domain_scores_gemma":[0.9987128,0.0003358375,0.0001830186,0.00009651597,0.0006238584,0.0000479805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001851034,0.0001660164,0.009223828,0.0001519275,0.000315375,0.00006639359,0.0005836781,0.00001003107,0.7500198,0.003146108,0.004095474,0.2303703],"study_design_scores_gemma":[0.003450431,0.0003332608,0.08652835,0.0008389603,0.0001152801,0.00003674245,0.0004820249,0.00002769369,0.8953077,0.002636696,0.0101068,0.0001360901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884483,0.006679771,0.0000184476,0.003848208,0.0003396486,0.0002333858,0.00000701052,0.00001184556,0.0004134188],"genre_scores_gemma":[0.9973717,0.001419569,0.00003945734,0.00001561566,0.0001187488,0.00002363992,0.00002584773,0.000005619773,0.000979798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2302342,"threshold_uncertainty_score":0.2944353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04246175484200099,"score_gpt":0.3533355260120882,"score_spread":0.3108737711700872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}