{"id":"W4408648268","doi":"10.2147/jir.s500822","title":"FLI1 Induces Plaque Psoriasis and Its Inhibition Attenuates Disease Progression","year":2025,"lang":"en","type":"article","venue":"Journal of Inflammation Research","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Plaque psoriasis; Psoriasis; FLI1; Disease; Medicine; Cancer research; Immunology; Internal medicine; Biology; Genetics; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002576679,0.0005558835,0.000526006,0.0005939996,0.0002104165,0.0003654785,0.0003170644,0.0004832858,0.002865545],"category_scores_gemma":[0.0001623056,0.000151749,0.0004093873,0.0002836661,0.0003065881,0.0001943402,0.000236474,0.001356213,0.0006742908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003544886,"about_ca_system_score_gemma":0.0003840123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006332959,"about_ca_topic_score_gemma":0.0007770764,"domain_scores_codex":[0.9998077,0.00002693862,0.00001448266,0.00003205365,0.00004908103,0.00006974977],"domain_scores_gemma":[0.9998833,0.00001419477,0.00002704943,0.00001036933,0.00001149256,0.0000536328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000667284,0.00046436,0.0001578633,0.0001840364,0.00002241118,0.00004185219,0.0000240141,0.0001659696,0.9881868,0.0001078238,0.0005692794,0.009408423],"study_design_scores_gemma":[0.0003863007,0.004840158,0.007447874,0.00004803568,0.00008322737,0.000346695,0.0000433431,0.002235958,0.9750713,0.000147504,0.009334732,0.00001501517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761341,0.0104824,0.003844608,0.0007864466,0.0002634033,0.0001872829,0.001139701,0.001274407,0.005887719],"genre_scores_gemma":[0.9901336,0.002679204,0.001837543,0.0003149249,0.0000684173,0.0001306287,0.001249027,0.00004992282,0.003536593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002865545,"threshold_uncertainty_score":0.009586215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04246175484200099,"score_gpt":0.3533355260120882,"score_spread":0.3108737711700872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}