{"id":"W4408648634","doi":"10.3390/plants14060954","title":"Exploring the Anti-Chagas Activity of Zanthoxylum chiloperone’s Seedlings Through Metabolomics and Protein–Ligand Docking","year":2025,"lang":"en","type":"article","venue":"Plants","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Metabolomics Innovation Centre; University of Alberta","funders":"Canadian Institutes of Health Research; Genome Alberta; Natural Sciences and Engineering Research Council of Canada; Consejo Nacional de Ciencia y Tecnología; Genome Canada","keywords":"Rutaceae; Alkaloid; Chemistry; Trypanosoma cruzi; Metabolomics; Squalene; Phytochemical; Lanosterol; Biochemistry; Traditional medicine; Biology; Stereochemistry; Botany; Chromatography; Sterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006779416,0.0003051155,0.000265138,0.0001554852,0.0001341481,0.0002661823,0.0002155314,0.0001868517,0.0009412962],"category_scores_gemma":[0.0000600315,0.00008384752,0.0003534639,0.0001398527,0.00007382096,0.0001701533,0.0001397711,0.0002968331,0.0001647874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002272073,"about_ca_system_score_gemma":0.0001938457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001919342,"about_ca_topic_score_gemma":0.004107335,"domain_scores_codex":[0.9999787,0.00000279851,9.633633e-7,0.000005337459,0.000007160082,0.000005111885],"domain_scores_gemma":[0.999985,0.000004707797,0.000003636155,0.000001092194,0.000002380545,0.000003101129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003699472,0.0001028344,0.002779692,0.0005178413,0.00009812597,0.0001976651,0.0000438009,0.01791312,0.9626055,0.000781967,0.0003632754,0.01422631],"study_design_scores_gemma":[0.0001981152,0.001491082,0.02480689,0.00006129023,0.0002633498,0.0003973852,0.0002942767,0.2517563,0.6992,0.0007867709,0.020649,0.00009548138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891632,0.002718988,0.004757235,0.0001248577,0.00001885722,0.00003603457,0.0009448147,0.0001979876,0.002038084],"genre_scores_gemma":[0.9877368,0.002462283,0.007765199,0.00003733943,0.000002803725,0.0000274158,0.0009321104,0.00001691047,0.001019097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001919342,"threshold_uncertainty_score":0.003816307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09668069792054144,"score_gpt":0.3215978425899385,"score_spread":0.224917144669397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}