{"id":"W4408653170","doi":"10.1101/2025.03.18.643960","title":"<i>MIR192</i> Upregulates GLP-1 Receptor and Improves Statin-Induced Impairment of Insulin Secretion","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Statin; Endocrinology; Internal medicine; Simvastatin; Atorvastatin; Insulin; Induced pluripotent stem cell; Biology; Medicine; Chemistry; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001873474,0.0003849473,0.000466023,0.0002560198,0.0002176114,0.0003837151,0.0002464525,0.0003169919,0.003410966],"category_scores_gemma":[0.0001510965,0.000189642,0.000417356,0.0001411278,0.0002001504,0.0001853012,0.000190954,0.0007232522,0.001039338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002634063,"about_ca_system_score_gemma":0.000178193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006835844,"about_ca_topic_score_gemma":0.0008963331,"domain_scores_codex":[0.9998227,0.0000265673,0.00002378177,0.00003822846,0.00004639569,0.00004240821],"domain_scores_gemma":[0.9999024,0.00001137766,0.00003519744,0.0000120231,0.00001392867,0.00002515254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001304939,0.0002883046,0.0003586064,0.00007829368,0.00003941786,0.00008330614,0.0000167775,0.00008704903,0.9918074,0.0001250335,0.001001899,0.004809046],"study_design_scores_gemma":[0.000290061,0.00247909,0.006435021,0.00001306215,0.0001069767,0.0005332884,0.0000507219,0.001073118,0.9766589,0.00006691257,0.01227658,0.00001630801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840036,0.001905343,0.003166744,0.0005691492,0.000352862,0.0001291764,0.002185573,0.001012157,0.006675464],"genre_scores_gemma":[0.98813,0.0009547257,0.003610685,0.0004807576,0.00006917454,0.0001274317,0.002262495,0.0001949124,0.004169774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003410966,"threshold_uncertainty_score":0.01141083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006925032252248224,"score_gpt":0.218378061164772,"score_spread":0.2114530289125238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}