{"id":"W4408654217","doi":"10.1089/bioe.2025.0010","title":"Lysosomal Ion Channels and Transporters: Recent Findings, Therapeutic Potential, and Technical Approaches","year":2025,"lang":"en","type":"review","venue":"Bioelectricity","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Ion channel; Transporter; Computational biology; Neuroscience; Computer science; Chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002953569,0.0004097371,0.0008427678,0.0001723158,0.0001214268,0.00006492544,0.0001858601,0.0006409495,0.000005520586],"category_scores_gemma":[0.00004042856,0.0003411187,0.0002492888,0.0003002457,0.0001173698,0.000003118855,0.00008363075,0.0002932759,0.000001148291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001938047,"about_ca_system_score_gemma":0.0001429808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009242677,"about_ca_topic_score_gemma":0.000002453462,"domain_scores_codex":[0.9982955,0.0001474887,0.0003680981,0.0007267478,0.0001291102,0.0003329964],"domain_scores_gemma":[0.999447,0.0000282971,0.0001150894,0.0002756102,0.00003217173,0.0001018685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003964782,0.00008580131,0.000007771082,0.002644449,0.0001856473,0.000005019765,0.000006157651,3.466106e-7,0.004591736,0.0001093673,0.0003591056,0.9919649],"study_design_scores_gemma":[0.0003902232,0.0003223284,0.00005393101,0.001004307,0.001246009,0.0001838348,0.000003946733,0.00001353938,0.002716937,0.00007022524,0.9933501,0.0006446124],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001322994,0.9964644,0.001257214,0.00005742585,0.0002112146,0.0005348026,0.0000435958,0.00003215594,0.00007615377],"genre_scores_gemma":[0.00943301,0.9895818,0.0001019937,0.00006537142,0.0003229256,0.00005250669,0.0002626049,0.00003376971,0.0001460546],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.992991,"threshold_uncertainty_score":0.9999041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04211177152654743,"score_gpt":0.283081834172817,"score_spread":0.2409700626462696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}