{"id":"W4408654217","doi":"10.1089/bioe.2025.0010","title":"Lysosomal Ion Channels and Transporters: Recent Findings, Therapeutic Potential, and Technical Approaches","year":2025,"lang":"en","type":"review","venue":"Bioelectricity","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Ion channel; Transporter; Computational biology; Neuroscience; Computer science; Chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006803507,0.000903047,0.001226182,0.002256726,0.0002512903,0.001188995,0.0008267763,0.00109926,0.002939914],"category_scores_gemma":[0.000705576,0.0003576732,0.0005157814,0.002182346,0.0005824463,0.001796342,0.0007466474,0.00207478,0.001973251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006565587,"about_ca_system_score_gemma":0.0009178402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006776074,"about_ca_topic_score_gemma":0.001116748,"domain_scores_codex":[0.9998042,0.0000267644,0.00003143051,0.0000406909,0.00007688452,0.0000200151],"domain_scores_gemma":[0.9997172,0.0001371835,0.00003007414,0.00001180675,0.00007206325,0.00003162715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001179792,0.00009653748,0.0001496889,0.01941766,0.00008077493,0.0003934629,0.00007195071,0.0005123342,0.00398493,0.007188809,0.02397683,0.9440091],"study_design_scores_gemma":[0.00002116051,0.0001182539,0.0004198492,0.001761015,0.00009395103,0.001678507,0.00004729591,0.0001119394,0.0008718987,0.002146316,0.9927089,0.00002089224],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001047496,0.9985905,0.0001393252,0.0001970051,0.0001806857,0.000003176181,0.00001017309,0.000006071703,0.0007682522],"genre_scores_gemma":[0.0004771248,0.9984908,0.0001923463,0.0001708303,0.0001996196,0.000005109091,0.00002036745,0.000001333975,0.0004425256],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002939914,"threshold_uncertainty_score":0.009835005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04211177152654743,"score_gpt":0.283081834172817,"score_spread":0.2409700626462696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}