{"id":"W4408660014","doi":"10.1038/s41375-025-02552-3","title":"Outcomes of frailty subgroups of older adults (age ≥ 70) treated with teclistamab: an International Myeloma Foundation immunotherapy database real-world analysis","year":2025,"lang":"en","type":"article","venue":"Leukemia","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"","keywords":"Multiple myeloma; Medicine; Immunotherapy; Foundation (evidence); Gerontology; Internal medicine; Oncology; Database; Cancer; History; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001455047,0.0004901867,0.001267407,0.001347138,0.000411034,0.001428376,0.0008717548,0.0006442948,0.001579631],"category_scores_gemma":[0.005052219,0.0003545388,0.002249861,0.002614977,0.0002702789,0.001114901,0.001413107,0.001021994,0.0002646703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001209352,"about_ca_system_score_gemma":0.0007802511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01930426,"about_ca_topic_score_gemma":0.02121408,"domain_scores_codex":[0.9986155,0.0002835703,0.0002849365,0.0004492824,0.0001810889,0.0001855168],"domain_scores_gemma":[0.9961546,0.0006721994,0.002129813,0.0003364854,0.0003037087,0.0004031214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005296335,0.0001411823,0.9816906,0.0002344884,0.003774582,0.0001230972,0.0001314799,0.0006537594,0.0001565761,0.0001182865,0.002900448,0.004778941],"study_design_scores_gemma":[0.0004211082,0.0003269172,0.9941578,0.00009459235,0.00129712,0.0003338639,0.0003871918,0.001525683,0.0000744197,0.000123118,0.001226034,0.00003225551],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9730662,0.001005032,0.0001620031,0.0001478731,0.00001038139,0.00004264878,0.02516538,0.00001002201,0.000390584],"genre_scores_gemma":[0.9672074,0.0004392976,0.0002787477,0.0001284454,0.00002343668,0.00008481814,0.03168109,0.00000776559,0.0001490264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01930426,"threshold_uncertainty_score":0.03838384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02078024877069166,"score_gpt":0.3399857507294998,"score_spread":0.3192055019588081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}