{"id":"W4408660014","doi":"10.1038/s41375-025-02552-3","title":"Outcomes of frailty subgroups of older adults (age ≥ 70) treated with teclistamab: an International Myeloma Foundation immunotherapy database real-world analysis","year":2025,"lang":"en","type":"article","venue":"Leukemia","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"","keywords":"Multiple myeloma; Medicine; Immunotherapy; Foundation (evidence); Gerontology; Internal medicine; Oncology; Database; Cancer; History; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001519476,0.0001916102,0.0005495323,0.0008328421,0.00004885967,0.00002028442,0.0001996917,0.0000624024,0.0004588889],"category_scores_gemma":[0.00006123693,0.0001378012,0.0001548366,0.001125202,0.0001296275,0.000217951,0.00004106264,0.0001346976,0.000005024267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004416955,"about_ca_system_score_gemma":0.0002468854,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01051305,"about_ca_topic_score_gemma":0.004102645,"domain_scores_codex":[0.9984455,0.00006870354,0.0004387093,0.000346585,0.000490699,0.0002098707],"domain_scores_gemma":[0.9985754,0.0001186025,0.0001953394,0.0007153195,0.0002991429,0.00009616277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003553708,0.000469532,0.9678479,0.00009000441,0.003866165,0.00009194964,0.0002132189,0.00001616193,0.003834951,0.0003971731,0.00003499258,0.01958426],"study_design_scores_gemma":[0.008628018,0.0002262025,0.9757491,0.0001692838,0.0004873071,0.000001774782,0.00009164641,0.001899748,0.01251199,0.00001383192,0.0001252516,0.0000957918],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940555,0.00002609748,0.0007717055,0.00009644676,0.00003210726,0.0004801947,0.0001619408,0.00004399662,0.004331981],"genre_scores_gemma":[0.9914162,0.0000983336,0.001902556,0.00006202065,0.00001894612,0.0000451061,0.002978779,0.0000177924,0.003460325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01948847,"threshold_uncertainty_score":0.996076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02078024877069166,"score_gpt":0.3399857507294998,"score_spread":0.3192055019588081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}