{"id":"W4408662974","doi":"10.1101/2025.03.17.643805","title":"Human Neonatal MR1T Cells Have Diverse TCR Usage, are Less Cytotoxic and are Unable to Respond to Many Common Childhood Pathogens","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Cytotoxic T cell; T-cell receptor; Biology; Immunology; Genetics; T cell; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002344358,0.0002251815,0.0003372486,0.0002485135,0.0003907862,0.0005681712,0.0002704431,0.0003365837,0.01006382],"category_scores_gemma":[0.0004354687,0.0001355464,0.0002489112,0.0003251763,0.0001821893,0.0001495783,0.0002590856,0.000672446,0.003178168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001845104,"about_ca_system_score_gemma":0.0002473211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001972663,"about_ca_topic_score_gemma":0.002435283,"domain_scores_codex":[0.9996966,0.00001960199,0.00002175505,0.0001144077,0.00007975323,0.00006783057],"domain_scores_gemma":[0.9997947,0.00003551643,0.00003290941,0.00002657167,0.000063182,0.00004715584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007135258,0.00004067862,0.00908273,0.0002542608,0.00003050241,0.0002783727,0.000253489,0.0002743608,0.971562,0.0001776827,0.002908861,0.01442352],"study_design_scores_gemma":[0.0001831422,0.001204826,0.1951163,0.0003075749,0.0002304326,0.004128625,0.001188552,0.003457562,0.7063054,0.0004894685,0.08730873,0.00007947264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.945028,0.004059267,0.01281764,0.0003991752,0.0001931268,0.0001744428,0.02703102,0.0004589562,0.009838517],"genre_scores_gemma":[0.9338062,0.002015562,0.01108143,0.001020893,0.00006857204,0.0004559633,0.03425451,0.0003308834,0.01696597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01006382,"threshold_uncertainty_score":0.03366685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01314056909151254,"score_gpt":0.2354937913801673,"score_spread":0.2223532222886547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}